Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study

J. M. Jeter, Jiali Han, M. E. Martinez, D. S. Alberts, A. A. Qureshi, D. Feskanich

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with lower risk of certain cancers, but data on the effect on skin cancer risk have been limited and contradictory. We prospectively examined whether use of NSAIDS or acetaminophen was associated with a lower risk of skin cancer in women. Methods The 92,125 Caucasian women in the Nurses' Health Study provided information on aspirin use in 1980. Other NSAIDs and acetaminophen were added in 1990. Medication use, frequency, and quantity were reassessed on biennial questionnaires. Through 2008, we confirmed 658 melanoma cases, 1,337 squamous cell carcinoma (SCC) cases, and had 15,079 self-reports of basal cell carcinoma (BCC). We used COX proportional hazards models to compute relative risks (RR) adjusted for known skin cancer risk factors. Results Neither aspirin nor non-aspirin NSAID use was associated with a lower risk of melanoma, SCC, or BCC, even for women with high quantity, frequency, or duration of use. Instead, we observed an increased risk of melanoma among current aspirin users (RR = 1.32, 95 % CI 1.03-1.70), though an increase of similar magnitude among past users and lack of a dose-response effect did not support a pharmacologic mechanism. We observed a mild reduction in SCC risk in current acetaminophen users (RR = 0.88, 95 % CI 0.75-1.02), with a linear decrease in risk with greater frequency of use (p = 0.04). Conclusions Aspirin and other NSAIDs were not associated with a lower risk of melanoma, SCC, or BCC in women. Our large, prospective study does not support a chemoprotective effect of NSAIDs against skin cancers.

Original languageEnglish (US)
Pages (from-to)1451-1461
Number of pages11
JournalCancer Causes and Control
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Skin Neoplasms
Acetaminophen
Anti-Inflammatory Agents
Nurses
Health
Pharmaceutical Preparations
Aspirin
Squamous Cell Carcinoma
Melanoma
Basal Cell Carcinoma
Proportional Hazards Models
Self Report
Prospective Studies

Keywords

  • (Cutaneous) Squamous cell carcinoma
  • Acetaminophen
  • Aspirin
  • Basal cell carcinoma
  • Melanoma
  • Non-steroidal anti-inflammatory medications (NSAIDs)
  • Skin cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study. / Jeter, J. M.; Han, Jiali; Martinez, M. E.; Alberts, D. S.; Qureshi, A. A.; Feskanich, D.

In: Cancer Causes and Control, Vol. 23, No. 9, 01.09.2012, p. 1451-1461.

Research output: Contribution to journalArticle

Jeter, J. M. ; Han, Jiali ; Martinez, M. E. ; Alberts, D. S. ; Qureshi, A. A. ; Feskanich, D. / Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 9. pp. 1451-1461.
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AU - Qureshi, A. A.

AU - Feskanich, D.

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