Nonadherence to Oral Antihyperglycemic Agents: Subsequent Hospitalization and Mortality among Patients with Type 2 Diabetes in Clinical Practice

Vivienne J. Zhu, Wanzhu Tu, Marc B. Rosenman, J. Marc Overhage

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

Using real-world clinical data from the Indiana Network for Patient Care, we analyzed the associations between non-adherence to oral antihyperglycemic agents (OHA) and subsequent diabetes-related hospitalization and all-cause mortality for patients with type 2 diabetes. OHA adherence was measured by the annual proportion of days covered (PDC) for 2008 and 2009. Among 24,067 eligible patients, 35,507 annual PDCs were formed. Over 90% (n=21,798) of the patients had a PDC less than 80%. In generalized linear mixed model analyses, OHA non-adherence is significantly associated with diabetes related hospitalizations (OR: 1.2; 95% CI [1.1,1.3]; p<0.0001). Older patients, white patients, or patients who had ischemic heart disease, stroke, or renal disease had higher odds of hospitalization. Similarly, OHA non-adherence increased subsequent mortality (OR: 1.3; 95% CI [1.02, 1.61]; p<0.0001). Patient age, male gender, income and presence of ischemic heart diseases, stroke, and renal disease were also significantly associated with subsequent all-cause death.

Original languageEnglish (US)
Title of host publicationMEDINFO 2015
Subtitle of host publicationeHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics
EditorsAndrew Georgiou, Indra Neil Sarkar, Paulo Mazzoncini de Azevedo Marques
PublisherIOS Press
Pages60-63
Number of pages4
ISBN (Electronic)9781614995630
DOIs
StatePublished - Jan 1 2015
Event15th World Congress on Health and Biomedical Informatics, MEDINFO 2015 - Sao Paulo, Brazil
Duration: Aug 19 2015Aug 23 2015

Publication series

NameStudies in Health Technology and Informatics
Volume216
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Other

Other15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
CountryBrazil
CitySao Paulo
Period8/19/158/23/15

Keywords

  • Health information exchange
  • hospitalization
  • medication adherence
  • mortality
  • type 2 diabetes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Fingerprint Dive into the research topics of 'Nonadherence to Oral Antihyperglycemic Agents: Subsequent Hospitalization and Mortality among Patients with Type 2 Diabetes in Clinical Practice'. Together they form a unique fingerprint.

  • Cite this

    Zhu, V. J., Tu, W., Rosenman, M. B., & Overhage, J. M. (2015). Nonadherence to Oral Antihyperglycemic Agents: Subsequent Hospitalization and Mortality among Patients with Type 2 Diabetes in Clinical Practice. In A. Georgiou, I. N. Sarkar, & P. M. de Azevedo Marques (Eds.), MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics (pp. 60-63). (Studies in Health Technology and Informatics; Vol. 216). IOS Press. https://doi.org/10.3233/978-1-61499-564-7-60