Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

Eric P. Stahl, Devinder S. Dhindsa, Suegene K. Lee, Pratik B. Sandesara, Naga Chalasani, Laurence S. Sperling

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolism are some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches.

Original languageEnglish (US)
Pages (from-to)948-963
Number of pages16
JournalJournal of the American College of Cardiology
Volume73
Issue number8
DOIs
StatePublished - Mar 5 2019

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Cardiovascular Diseases
Cardiomyopathies
Lipid Metabolism
Insulin Resistance
Cardiac Arrhythmias
Atherosclerosis
Oxidative Stress
Non-alcoholic Fatty Liver Disease
Inflammation
Morbidity
Mortality
Liver
Therapeutics

Keywords

  • cardiovascular disease
  • metabolic syndrome
  • nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nonalcoholic Fatty Liver Disease and the Heart : JACC State-of-the-Art Review. / Stahl, Eric P.; Dhindsa, Devinder S.; Lee, Suegene K.; Sandesara, Pratik B.; Chalasani, Naga; Sperling, Laurence S.

In: Journal of the American College of Cardiology, Vol. 73, No. 8, 05.03.2019, p. 948-963.

Research output: Contribution to journalReview article

Stahl, Eric P. ; Dhindsa, Devinder S. ; Lee, Suegene K. ; Sandesara, Pratik B. ; Chalasani, Naga ; Sperling, Laurence S. / Nonalcoholic Fatty Liver Disease and the Heart : JACC State-of-the-Art Review. In: Journal of the American College of Cardiology. 2019 ; Vol. 73, No. 8. pp. 948-963.
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