Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

Eric P. Stahl, Devinder S. Dhindsa, Suegene K. Lee, Pratik B. Sandesara, Naga P. Chalasani, Laurence S. Sperling

Research output: Contribution to journalReview article

18 Scopus citations


Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolism are some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches.

Original languageEnglish (US)
Pages (from-to)948-963
Number of pages16
JournalJournal of the American College of Cardiology
Issue number8
StatePublished - Mar 5 2019


  • cardiovascular disease
  • metabolic syndrome
  • nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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