Nonalcoholic fatty liver disease in individuals with severe obesity

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Obesity is a dominant risk factor for developing NAFLD and subjects with severe obesity have a very high prevalence of NAFLD. Severely obese people with NAFLD are more likely to have advanced histologic forms of NAFLD than those with less severe forms of obesity. In general, serum ALT levels do not correlate with hepatic histology in the severely obese with NAFLD. Older age, higher BMI, and the presence of diabetes mellitus predict advanced hepatic histology in severely obese patients with NAFLD. Weight loss induced by gastric weight loss surgery or very low calorie diets leads to significant improvement in hepatic steatosis but in some patients it may lead to worsening hepatic inflammation or fibrosis. In the severely obese who are subjected to a very low calorie diet, the target weight loss should be less than 1.6 kg/week.

Original languageEnglish
Pages (from-to)535-547
Number of pages13
JournalClinics in Liver Disease
Volume8
Issue number3
DOIs
StatePublished - Aug 2004

Fingerprint

Morbid Obesity
Weight Loss
Caloric Restriction
Liver
Histology
Non-alcoholic Fatty Liver Disease
Stomach
Diabetes Mellitus
Fibrosis
Obesity
Inflammation
Serum

ASJC Scopus subject areas

  • Hepatology

Cite this

Nonalcoholic fatty liver disease in individuals with severe obesity. / Haynes, Paul; Liangpunsakul, Suthat; Chalasani, Naga.

In: Clinics in Liver Disease, Vol. 8, No. 3, 08.2004, p. 535-547.

Research output: Contribution to journalArticle

@article{1ae1d3b5e99b452c979a8fcb5ee624c7,
title = "Nonalcoholic fatty liver disease in individuals with severe obesity",
abstract = "Obesity is a dominant risk factor for developing NAFLD and subjects with severe obesity have a very high prevalence of NAFLD. Severely obese people with NAFLD are more likely to have advanced histologic forms of NAFLD than those with less severe forms of obesity. In general, serum ALT levels do not correlate with hepatic histology in the severely obese with NAFLD. Older age, higher BMI, and the presence of diabetes mellitus predict advanced hepatic histology in severely obese patients with NAFLD. Weight loss induced by gastric weight loss surgery or very low calorie diets leads to significant improvement in hepatic steatosis but in some patients it may lead to worsening hepatic inflammation or fibrosis. In the severely obese who are subjected to a very low calorie diet, the target weight loss should be less than 1.6 kg/week.",
author = "Paul Haynes and Suthat Liangpunsakul and Naga Chalasani",
year = "2004",
month = "8",
doi = "10.1016/j.cld.2004.04.007",
language = "English",
volume = "8",
pages = "535--547",
journal = "Clinics in Liver Disease",
issn = "1089-3261",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Nonalcoholic fatty liver disease in individuals with severe obesity

AU - Haynes, Paul

AU - Liangpunsakul, Suthat

AU - Chalasani, Naga

PY - 2004/8

Y1 - 2004/8

N2 - Obesity is a dominant risk factor for developing NAFLD and subjects with severe obesity have a very high prevalence of NAFLD. Severely obese people with NAFLD are more likely to have advanced histologic forms of NAFLD than those with less severe forms of obesity. In general, serum ALT levels do not correlate with hepatic histology in the severely obese with NAFLD. Older age, higher BMI, and the presence of diabetes mellitus predict advanced hepatic histology in severely obese patients with NAFLD. Weight loss induced by gastric weight loss surgery or very low calorie diets leads to significant improvement in hepatic steatosis but in some patients it may lead to worsening hepatic inflammation or fibrosis. In the severely obese who are subjected to a very low calorie diet, the target weight loss should be less than 1.6 kg/week.

AB - Obesity is a dominant risk factor for developing NAFLD and subjects with severe obesity have a very high prevalence of NAFLD. Severely obese people with NAFLD are more likely to have advanced histologic forms of NAFLD than those with less severe forms of obesity. In general, serum ALT levels do not correlate with hepatic histology in the severely obese with NAFLD. Older age, higher BMI, and the presence of diabetes mellitus predict advanced hepatic histology in severely obese patients with NAFLD. Weight loss induced by gastric weight loss surgery or very low calorie diets leads to significant improvement in hepatic steatosis but in some patients it may lead to worsening hepatic inflammation or fibrosis. In the severely obese who are subjected to a very low calorie diet, the target weight loss should be less than 1.6 kg/week.

UR - http://www.scopus.com/inward/record.url?scp=4344629376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344629376&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2004.04.007

DO - 10.1016/j.cld.2004.04.007

M3 - Article

C2 - 15331062

AN - SCOPUS:4344629376

VL - 8

SP - 535

EP - 547

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

IS - 3

ER -