Parathyroid hormone (PTH) was measured by radioimmunoassay in the plasma of twenty patients with surgically proven primary hyperparathyroidism during intravenous infusions of calcium and/or EDTA. All patients studied showed significant increases in plasma PTH during induced hypocalcaemia and significant decreases in plasma PTH during induced hypercalcaemia. The secretion of para thyroid hormone was not autonomous in these patients with primary hyperparathyroidism, regardless of histological type, but varied with induced changes in serum calcium concentration. The presence of immunoreactive hormonal sub‐fragments in plasma seems the most likely explanation for the sharp contrast between our data and earlier studies. In spite of the difficulties presented by this complex pattern of hormonal metabolism, the radioimmunoassay for parathyroid hormone is clinically quite useful, particularly in the differential diagnosis of hypercalcaemia.
|Original language||English (US)|
|Number of pages||12|
|State||Published - Jul 1972|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism