Noncoding RNAs in breast cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in RNA sequencing technologies have unveiled the complexity of RNA world outdating the traditional view thatmany noncoding RNA (ncRNA) transcripts are transcriptional noise, while the protein coding genes are important players in cancer signaling. Accumulating evidence suggests that they are not only key regulators of gene expression, but also direct targets of cancer pathways. These aremainly classified according to their size: microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) being themost studied. The field has rapidly expanded and it is impossible to cover all the nuances in a single chapter. Noncoding RNAs, including miRNAs (~22 nucleotides long RNAs) and lncRNAs (>200 nucleotides), regulate gene expression at the transcriptional levels or post-transcriptionally by modulating the function of transcription factors, directing chromatin reorganization and modification, or by inhibiting the translation or stability of messenger RNA (mRNA).Here, we provide an overviewof the role of ncRNAs in breast cancer and their prognostic and predictive potential in the clinical practice.

Original languageEnglish (US)
Title of host publicationMolecular Pathology of Breast Cancer
PublisherSpringer International Publishing
Pages345-364
Number of pages20
ISBN (Electronic)9783319417615
ISBN (Print)9783319417592
DOIs
StatePublished - Jan 1 2016

Keywords

  • Breast cancer
  • Gene regulation
  • Human genome and whole transcriptome
  • Long-noncoding RNA
  • Noncoding RNA
  • RNA-sequencing
  • Small RNA
  • Transcriptional noise

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Polar, Y., & Badve, S. (2016). Noncoding RNAs in breast cancer. In Molecular Pathology of Breast Cancer (pp. 345-364). Springer International Publishing. https://doi.org/10.1007/978-3-319-41761-5_22