Nonesophageal eosinophilic gastrointestinal disorders: Clinical care and future directions

Sara Naramore, Sandeep K. Gupta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Eosinophilic gastrointestinal disorders are a set of conditions with a wide range of clinical manifestations and treatment modalities. The disorders are suspected to result from an abnormal inflammatory response to allergen (s), and individuals may develop a relapsing or chronic disease, if the allergen is not eliminated. Mechanisms of disease pathogenesis, including the humoral immune response, need to be fully elucidated. A variety of therapies are used, although there is a lack of well-defined randomized, prospective studies. Other therapeutic options are needed as the current treatments have potential concerns; elimination diets may impair a child's quality of life, and corticosteroids have adverse risks with long-term use. We review what is known about nonesophageal eosinophilic gastrointestinal disorders, and discuss research investigations which need to be conducted to facilitate diagnosis and enhance treatment methods.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalJournal of pediatric gastroenterology and nutrition
Volume67
Issue number3
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Diet elimination therapy
  • Eosinophilic gastroenteritis
  • Intestinal eosinophilia
  • Therapeutic biologic agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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