Nonhematological benefits of iron

Research output: Contribution to journalReview article

49 Scopus citations


Iron deficiency anemia is common in people with chronic kidney disease (CKD) and its importance in supporting erythropoiesis is unquestioned especially in those patients treated with erythropoietin. Clinical symptomatology such as fatigability, cold intolerance, failure to concentrate and poor effort intolerance is often attributed to anemia or uremia. That iron deficiency, per se, can cause these symptoms is poorly recognized. Clinical and animal studies that support the benefits of iron supplementation, independent of increasing hemoglobin, such as those on immune function, physical performance, thermoregulation, cognition, and restless leg syndrome and aluminum absorption is the subject of this narrative review.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalAmerican journal of nephrology
Issue number6
StatePublished - Oct 1 2007


  • Anemia
  • Chronic kidney disease
  • Cognitive function
  • Iron deficiency
  • Physical performance
  • Quality of life
  • Thermoregulation

ASJC Scopus subject areas

  • Nephrology

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