The weighted-spirometer method for noninvasive determination of static total respiratory system compliance (Crs) was adapted for use in infants. Ten normal newborns and 5 infants with bronchopulmonary dysplasia (BPD) were studied. The newborns had a mean Crs of 3.8 ml/cm H2O. Their mean specific Crs was 1.13 ml/cm H2O/kg body weight and 0.075 ml/cm H2O/cm body length. These Crs values were similar to those reported by other investigators who used the Hering-Breuer airway occlusion technique. The infants with BPD, who were of the same weight, height, and postconception age as the normal newborns, had significantly (p < 0.05) lower mean specific Crs (0.60 ml/cm H2O/kg body weight and 0.047 ml/cm H2O/cm body length) relative to the normal newborns. These data suggest that intrinsic changes in lung elastic characteristics may contribute to the reduced lung compliance of infants with BPD. The weighted-spirometer method for measuring Crs is a potential tool for the noninvasive study of the elastic properties of the respiratory system during infancy in health and disease.
|Original language||English (US)|
|Number of pages||6|
|Journal||American Review of Respiratory Disease|
|State||Published - Jan 1 1984|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine