Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography

Markus Schwaiger, Victor Kalff, Karen Rosenspire, Michael S. Haka, Edgar Molina, Gary Hutchins, Michael Deeb, Edwin Wolfe, Donald M. Wieland

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

The noninvasive functional characterization of the cardiac sympathetic nervous system by imaging techniques may provide important pathophysiological information in various cardiac disease states. Hydroxyephedrine labeled with carbon 11 has been developed as a new catecholamine analogue to be used in the in vivo evaluation of presynaptic adrenergic nerve terminals by positron emission tomography (PET). To determine the feasibility of this imaging approach in the human heart, six normal volunteers and five patients with recent cardiac transplants underwent dynamic PET imaging after intravenous injection of 20 mCi [11C] hydroxyephedrine. Blood and myocardial tracer kinetics were assessed using a regions-of-interest approach. In normal volunteers, blood 11C activity cleared rapidly, whereas myocardium retained 11C activity with a long tissue half-life. Relative tracer retention in the myocardium averaged 79±31% of peak activity at 60 minutes after tracer injection. The heart-to-blood 11C activity ratio exceeded 6:1 as soon as 30 minutes after tracer injection, yielding excellent image quality. Little regional variation of tracer retention was observed, indicating homogeneous sympathetic innervation throughout the left ventricle. In the transplant recipients, myocardial [11C]hydroxyephedrine retention at 60 minutes was significantly less (-82%) than that of normal volunteers, indicating only little non-neuronal binding of the tracer in the denervated human heart. Thus, [11C] hydroxyephedrine, in combination with dynamic PET imaging, allows the noninvasive delineation of myocardial adrenergic nerve terminals. Tracer kinetic modeling may permit quantitative assessment of myocardial catecholamine uptake, which will in turn provide insights into the effects of various disease processes on the neuronal integrity of the heart.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
JournalCirculation
Volume82
Issue number2
StatePublished - Aug 1990
Externally publishedYes

Fingerprint

Sympathetic Nervous System
Positron-Emission Tomography
Healthy Volunteers
Adrenergic Agents
Catecholamines
Myocardium
Injections
Intravenous Injections
Heart Ventricles
Half-Life
Heart Diseases
Carbon
Transplants

Keywords

  • [C]hydroxyephedrine
  • Nervous system, sympathetic
  • Positron emission tomography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Schwaiger, M., Kalff, V., Rosenspire, K., Haka, M. S., Molina, E., Hutchins, G., ... Wieland, D. M. (1990). Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation, 82(2), 457-464.

Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. / Schwaiger, Markus; Kalff, Victor; Rosenspire, Karen; Haka, Michael S.; Molina, Edgar; Hutchins, Gary; Deeb, Michael; Wolfe, Edwin; Wieland, Donald M.

In: Circulation, Vol. 82, No. 2, 08.1990, p. 457-464.

Research output: Contribution to journalArticle

Schwaiger, M, Kalff, V, Rosenspire, K, Haka, MS, Molina, E, Hutchins, G, Deeb, M, Wolfe, E & Wieland, DM 1990, 'Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography', Circulation, vol. 82, no. 2, pp. 457-464.
Schwaiger M, Kalff V, Rosenspire K, Haka MS, Molina E, Hutchins G et al. Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation. 1990 Aug;82(2):457-464.
Schwaiger, Markus ; Kalff, Victor ; Rosenspire, Karen ; Haka, Michael S. ; Molina, Edgar ; Hutchins, Gary ; Deeb, Michael ; Wolfe, Edwin ; Wieland, Donald M. / Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. In: Circulation. 1990 ; Vol. 82, No. 2. pp. 457-464.
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