Noninvasive glucose monitoring with a contact lens and smartphone

You Rong Lin, Chin Chi Hung, Hsien Yi Chiu, Bo Han Chang, Bor Ran Li, Sheng Jen Cheng, Jia Wei Yang, Shien Fong Lin, Guan Yu Chen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using a portable and noninvasive contact lens as an ideal sensor for diabetes patients whose tear fluid contains glucose. The key feature is the reversible covalent interaction between boronic acid and glucose, which can provide a noninvasive glucose sensor for diabetes patients. We present a phenylboronic acid (PBA)-based HEMA contact lens that exhibits a reversible swelling/shrinking effect to change its thickness. The difference in thickness can be detected in a picture taken with a smartphone and analyzed using software. Our novel technique offers the following capabilities: (i) non-enzymatic and continuous glucose detection with the contact lens; (ii) no need for an embedded circuit and power source for the glucose sensor; and (iii) the use of a smartphone to detect the change in thickness of the contact lens with no need for additional photo-sensors. This technique is promising for a noninvasive measurement of the glucose level and simple implementation of glucose sensing with a smartphone.

Original languageEnglish (US)
Article number3208
JournalSensors (Switzerland)
Volume18
Issue number10
DOIs
StatePublished - Oct 2018
Externally publishedYes

Keywords

  • Contact lens
  • Glucose monitoring
  • Image detection
  • Noninvasive
  • Smartphone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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  • Cite this

    Lin, Y. R., Hung, C. C., Chiu, H. Y., Chang, B. H., Li, B. R., Cheng, S. J., Yang, J. W., Lin, S. F., & Chen, G. Y. (2018). Noninvasive glucose monitoring with a contact lens and smartphone. Sensors (Switzerland), 18(10), [3208]. https://doi.org/10.3390/s18103208