Noninvasive mesoscopic imaging of actinic skin damage using spatial frequency domain imaging

Jeffrey B. Travers, Chien Poon, Daniel J. Rohrbach, Nathan M. Weir, Elizabeth Cates, Faye Hager, Ulas Sunar

Research output: Contribution to journalArticle

7 Scopus citations


For prevention and accurate intervention planning, it is crucial to predict if lesions will progress towards cancer. In this study, we investigated the change in optical properties and vascular parameters to characterize skin tissue from mild photodamage to actinic keratosis (AK). Multi-wavelength spatial frequency domain imaging (SFDI) measurements were performed on three patients with clinically normal skin, as well as pre-cancerous actinic keratosis lesions. Our results indicate that there exist significant differences in both optical and vascular parameters between these patients, and that these parameters can be early biomarkers of neoplasia. Ultimately, clinicians can use this noninvasive approach for frequent monitoring of high-risk population.

Original languageEnglish (US)
Article number#291668
JournalBiomedical Optics Express
Issue number6
StatePublished - Jun 1 2017
Externally publishedYes


  • Dermatology
  • Imaging systems
  • Multispectral and hyperspectral imaging
  • Tissue characterization

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Noninvasive mesoscopic imaging of actinic skin damage using spatial frequency domain imaging'. Together they form a unique fingerprint.

  • Cite this