Noninvasive surgery of prostate tissue by high intensity focused ultrasound

An updated report

N. T. Sanghvi, Richard Foster, Richard Bihrle, R. Casey, T. Uchida, M. H. Phillips, J. Syrus, A. V. Zaitsev, K. W. Marich, F. J. Fry

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Objective: To establish clinical efficacy and safety of High Intensity Focused Ultrasound (HIFU) for the treatment of benign prostatic hyperplasia (BPH) in a multiple site clinical study. Methods: Seven clinical sites were set up for the studies, five in the USA, one in Canada and one in Japan respectively. Sixty two patients were enrolled in these three studies. Transrectal ultrasound probes made to produce sufficient acoustic power required for focused ultrasound surgery of the prostate as well as to perform imaging of the prostate, were employed in the study. The probes ware made of 2.5, 3,0, 3.5, 4.0 and 4.5 cm focal length transducers to treat varying prostate sizes and shapes and operated at 4 MHz frequency for both imaging and treatment. The employed ultrasound device produced both transverse and longitudinal images of the prostate on the same display. The images were used for selection of tissue volume, treatment planning and monitoring of tissue during the HIFU treatment cycle. The patients in the USA and Canada were followed for two years and those in Japan were followed for one year on a regular interval. The results were evaluated for changes in the peak flow rate (Qmax in ml/s), quality of life (QOL) and International Prostate Symptom Score (IPSS). Results: The average pre/post treatment results at 180 days were significantly different for Qmax, QOL and IPSS 8.5/14.2 (ml/s), 4.7/2.1 and 22/10 respectively. Conclusion: Under this protocol, HIFU was found safe and efficacious for the treatment of BPH. The HIFU treatment produced statistically significant results for the parameters measured with least complications. Additionally, the HIFU treatment was found to be durable.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalEuropean Journal of Ultrasound
Volume9
Issue number1
DOIs
StatePublished - Mar 1999

Fingerprint

surgery
Surgery
Prostate
Ultrasonics
Tissue
Prostatic Hyperplasia
Therapeutics
Canada
Japan
Quality of Life
Imaging techniques
probes
Transducers
Acoustics
planning
safety
transducers
flow velocity
Display devices
Flow rate

Keywords

  • Focused ultrasound
  • High intensity
  • Non-invasive surgery
  • Prostate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Bioengineering
  • Acoustics and Ultrasonics
  • Chemical Engineering(all)

Cite this

Noninvasive surgery of prostate tissue by high intensity focused ultrasound : An updated report. / Sanghvi, N. T.; Foster, Richard; Bihrle, Richard; Casey, R.; Uchida, T.; Phillips, M. H.; Syrus, J.; Zaitsev, A. V.; Marich, K. W.; Fry, F. J.

In: European Journal of Ultrasound, Vol. 9, No. 1, 03.1999, p. 19-29.

Research output: Contribution to journalArticle

Sanghvi, NT, Foster, R, Bihrle, R, Casey, R, Uchida, T, Phillips, MH, Syrus, J, Zaitsev, AV, Marich, KW & Fry, FJ 1999, 'Noninvasive surgery of prostate tissue by high intensity focused ultrasound: An updated report', European Journal of Ultrasound, vol. 9, no. 1, pp. 19-29. https://doi.org/10.1016/S0929-8266(99)00010-5
Sanghvi, N. T. ; Foster, Richard ; Bihrle, Richard ; Casey, R. ; Uchida, T. ; Phillips, M. H. ; Syrus, J. ; Zaitsev, A. V. ; Marich, K. W. ; Fry, F. J. / Noninvasive surgery of prostate tissue by high intensity focused ultrasound : An updated report. In: European Journal of Ultrasound. 1999 ; Vol. 9, No. 1. pp. 19-29.
@article{7e2c764a39f54f67a4482faeb2172d70,
title = "Noninvasive surgery of prostate tissue by high intensity focused ultrasound: An updated report",
abstract = "Objective: To establish clinical efficacy and safety of High Intensity Focused Ultrasound (HIFU) for the treatment of benign prostatic hyperplasia (BPH) in a multiple site clinical study. Methods: Seven clinical sites were set up for the studies, five in the USA, one in Canada and one in Japan respectively. Sixty two patients were enrolled in these three studies. Transrectal ultrasound probes made to produce sufficient acoustic power required for focused ultrasound surgery of the prostate as well as to perform imaging of the prostate, were employed in the study. The probes ware made of 2.5, 3,0, 3.5, 4.0 and 4.5 cm focal length transducers to treat varying prostate sizes and shapes and operated at 4 MHz frequency for both imaging and treatment. The employed ultrasound device produced both transverse and longitudinal images of the prostate on the same display. The images were used for selection of tissue volume, treatment planning and monitoring of tissue during the HIFU treatment cycle. The patients in the USA and Canada were followed for two years and those in Japan were followed for one year on a regular interval. The results were evaluated for changes in the peak flow rate (Qmax in ml/s), quality of life (QOL) and International Prostate Symptom Score (IPSS). Results: The average pre/post treatment results at 180 days were significantly different for Qmax, QOL and IPSS 8.5/14.2 (ml/s), 4.7/2.1 and 22/10 respectively. Conclusion: Under this protocol, HIFU was found safe and efficacious for the treatment of BPH. The HIFU treatment produced statistically significant results for the parameters measured with least complications. Additionally, the HIFU treatment was found to be durable.",
keywords = "Focused ultrasound, High intensity, Non-invasive surgery, Prostate",
author = "Sanghvi, {N. T.} and Richard Foster and Richard Bihrle and R. Casey and T. Uchida and Phillips, {M. H.} and J. Syrus and Zaitsev, {A. V.} and Marich, {K. W.} and Fry, {F. J.}",
year = "1999",
month = "3",
doi = "10.1016/S0929-8266(99)00010-5",
language = "English",
volume = "9",
pages = "19--29",
journal = "European Journal of Ultrasound",
issn = "0929-8266",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Noninvasive surgery of prostate tissue by high intensity focused ultrasound

T2 - An updated report

AU - Sanghvi, N. T.

AU - Foster, Richard

AU - Bihrle, Richard

AU - Casey, R.

AU - Uchida, T.

AU - Phillips, M. H.

AU - Syrus, J.

AU - Zaitsev, A. V.

AU - Marich, K. W.

AU - Fry, F. J.

PY - 1999/3

Y1 - 1999/3

N2 - Objective: To establish clinical efficacy and safety of High Intensity Focused Ultrasound (HIFU) for the treatment of benign prostatic hyperplasia (BPH) in a multiple site clinical study. Methods: Seven clinical sites were set up for the studies, five in the USA, one in Canada and one in Japan respectively. Sixty two patients were enrolled in these three studies. Transrectal ultrasound probes made to produce sufficient acoustic power required for focused ultrasound surgery of the prostate as well as to perform imaging of the prostate, were employed in the study. The probes ware made of 2.5, 3,0, 3.5, 4.0 and 4.5 cm focal length transducers to treat varying prostate sizes and shapes and operated at 4 MHz frequency for both imaging and treatment. The employed ultrasound device produced both transverse and longitudinal images of the prostate on the same display. The images were used for selection of tissue volume, treatment planning and monitoring of tissue during the HIFU treatment cycle. The patients in the USA and Canada were followed for two years and those in Japan were followed for one year on a regular interval. The results were evaluated for changes in the peak flow rate (Qmax in ml/s), quality of life (QOL) and International Prostate Symptom Score (IPSS). Results: The average pre/post treatment results at 180 days were significantly different for Qmax, QOL and IPSS 8.5/14.2 (ml/s), 4.7/2.1 and 22/10 respectively. Conclusion: Under this protocol, HIFU was found safe and efficacious for the treatment of BPH. The HIFU treatment produced statistically significant results for the parameters measured with least complications. Additionally, the HIFU treatment was found to be durable.

AB - Objective: To establish clinical efficacy and safety of High Intensity Focused Ultrasound (HIFU) for the treatment of benign prostatic hyperplasia (BPH) in a multiple site clinical study. Methods: Seven clinical sites were set up for the studies, five in the USA, one in Canada and one in Japan respectively. Sixty two patients were enrolled in these three studies. Transrectal ultrasound probes made to produce sufficient acoustic power required for focused ultrasound surgery of the prostate as well as to perform imaging of the prostate, were employed in the study. The probes ware made of 2.5, 3,0, 3.5, 4.0 and 4.5 cm focal length transducers to treat varying prostate sizes and shapes and operated at 4 MHz frequency for both imaging and treatment. The employed ultrasound device produced both transverse and longitudinal images of the prostate on the same display. The images were used for selection of tissue volume, treatment planning and monitoring of tissue during the HIFU treatment cycle. The patients in the USA and Canada were followed for two years and those in Japan were followed for one year on a regular interval. The results were evaluated for changes in the peak flow rate (Qmax in ml/s), quality of life (QOL) and International Prostate Symptom Score (IPSS). Results: The average pre/post treatment results at 180 days were significantly different for Qmax, QOL and IPSS 8.5/14.2 (ml/s), 4.7/2.1 and 22/10 respectively. Conclusion: Under this protocol, HIFU was found safe and efficacious for the treatment of BPH. The HIFU treatment produced statistically significant results for the parameters measured with least complications. Additionally, the HIFU treatment was found to be durable.

KW - Focused ultrasound

KW - High intensity

KW - Non-invasive surgery

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=0032912062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032912062&partnerID=8YFLogxK

U2 - 10.1016/S0929-8266(99)00010-5

DO - 10.1016/S0929-8266(99)00010-5

M3 - Article

VL - 9

SP - 19

EP - 29

JO - European Journal of Ultrasound

JF - European Journal of Ultrasound

SN - 0929-8266

IS - 1

ER -