Noninvasive ultrasound produced volume lesion in prostate

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

High intensity focused ultrasound has been used experimentally to ablate hepatic, brain, and subcutaneous tumors without damaging adjacent tissues. We report our pilot experience in dogs using this modality to ablate prostatic tissue. Six dogs subjected to acute injury were sacrificed one hour after focused ultrasound ablation; four dogs subjected to chronic injury wee sacrificed two, four, six, and twelve weeks post ablation. The pathology of the acute injury and chronic response to this injury is presented. High volume ablation was created without injury to adjacent tissue. Grossly, the post ablation prostate appears identical to the post TUR-P defect. Subsequently a combined imaging/therapy transrectal transducer has been developed and has been used in six dogs. The size and appearance of this probe is similar to current commercially available transrectal imaging probes. Prostate ablation was successful in all dogs and no injury to the rectal wall was apparent when energy levels were appropriate. Again, the post ablation prostate resembled a TUR-P defect. The implications of these findings using this new modality are potentially immense. Plans for human trials are being formulated.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGrahm M Watson, Rudolf W. Steiner, Joseph J. Pietrafitta
PublisherPubl by Int Soc for Optical Engineering
Pages47
Number of pages1
Volume1421
StatePublished - 1991
EventProceedings of Lasers in Urology, Laparoscopy, and General Surgery - Los Angeles, CA, USA
Duration: Jan 21 1991Jan 23 1991

Other

OtherProceedings of Lasers in Urology, Laparoscopy, and General Surgery
CityLos Angeles, CA, USA
Period1/21/911/23/91

Fingerprint

Ablation
dogs
lesions
ablation
Ultrasonics
Tissue
Imaging techniques
Defects
probes
defects
pathology
Pathology
Electron energy levels
brain
Tumors
Transducers
therapy
Brain
transducers
tumors

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Foster, R. (1991). Noninvasive ultrasound produced volume lesion in prostate. In G. M. Watson, R. W. Steiner, & J. J. Pietrafitta (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1421, pp. 47). Publ by Int Soc for Optical Engineering.

Noninvasive ultrasound produced volume lesion in prostate. / Foster, Richard.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Grahm M Watson; Rudolf W. Steiner; Joseph J. Pietrafitta. Vol. 1421 Publ by Int Soc for Optical Engineering, 1991. p. 47.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Foster, R 1991, Noninvasive ultrasound produced volume lesion in prostate. in GM Watson, RW Steiner & JJ Pietrafitta (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1421, Publ by Int Soc for Optical Engineering, pp. 47, Proceedings of Lasers in Urology, Laparoscopy, and General Surgery, Los Angeles, CA, USA, 1/21/91.
Foster R. Noninvasive ultrasound produced volume lesion in prostate. In Watson GM, Steiner RW, Pietrafitta JJ, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1421. Publ by Int Soc for Optical Engineering. 1991. p. 47
Foster, Richard. / Noninvasive ultrasound produced volume lesion in prostate. Proceedings of SPIE - The International Society for Optical Engineering. editor / Grahm M Watson ; Rudolf W. Steiner ; Joseph J. Pietrafitta. Vol. 1421 Publ by Int Soc for Optical Engineering, 1991. pp. 47
@inproceedings{3c405e7f6c42483cbc4bea53355dbc80,
title = "Noninvasive ultrasound produced volume lesion in prostate",
abstract = "High intensity focused ultrasound has been used experimentally to ablate hepatic, brain, and subcutaneous tumors without damaging adjacent tissues. We report our pilot experience in dogs using this modality to ablate prostatic tissue. Six dogs subjected to acute injury were sacrificed one hour after focused ultrasound ablation; four dogs subjected to chronic injury wee sacrificed two, four, six, and twelve weeks post ablation. The pathology of the acute injury and chronic response to this injury is presented. High volume ablation was created without injury to adjacent tissue. Grossly, the post ablation prostate appears identical to the post TUR-P defect. Subsequently a combined imaging/therapy transrectal transducer has been developed and has been used in six dogs. The size and appearance of this probe is similar to current commercially available transrectal imaging probes. Prostate ablation was successful in all dogs and no injury to the rectal wall was apparent when energy levels were appropriate. Again, the post ablation prostate resembled a TUR-P defect. The implications of these findings using this new modality are potentially immense. Plans for human trials are being formulated.",
author = "Richard Foster",
year = "1991",
language = "English",
volume = "1421",
pages = "47",
editor = "Watson, {Grahm M} and Steiner, {Rudolf W.} and Pietrafitta, {Joseph J.}",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Publ by Int Soc for Optical Engineering",

}

TY - GEN

T1 - Noninvasive ultrasound produced volume lesion in prostate

AU - Foster, Richard

PY - 1991

Y1 - 1991

N2 - High intensity focused ultrasound has been used experimentally to ablate hepatic, brain, and subcutaneous tumors without damaging adjacent tissues. We report our pilot experience in dogs using this modality to ablate prostatic tissue. Six dogs subjected to acute injury were sacrificed one hour after focused ultrasound ablation; four dogs subjected to chronic injury wee sacrificed two, four, six, and twelve weeks post ablation. The pathology of the acute injury and chronic response to this injury is presented. High volume ablation was created without injury to adjacent tissue. Grossly, the post ablation prostate appears identical to the post TUR-P defect. Subsequently a combined imaging/therapy transrectal transducer has been developed and has been used in six dogs. The size and appearance of this probe is similar to current commercially available transrectal imaging probes. Prostate ablation was successful in all dogs and no injury to the rectal wall was apparent when energy levels were appropriate. Again, the post ablation prostate resembled a TUR-P defect. The implications of these findings using this new modality are potentially immense. Plans for human trials are being formulated.

AB - High intensity focused ultrasound has been used experimentally to ablate hepatic, brain, and subcutaneous tumors without damaging adjacent tissues. We report our pilot experience in dogs using this modality to ablate prostatic tissue. Six dogs subjected to acute injury were sacrificed one hour after focused ultrasound ablation; four dogs subjected to chronic injury wee sacrificed two, four, six, and twelve weeks post ablation. The pathology of the acute injury and chronic response to this injury is presented. High volume ablation was created without injury to adjacent tissue. Grossly, the post ablation prostate appears identical to the post TUR-P defect. Subsequently a combined imaging/therapy transrectal transducer has been developed and has been used in six dogs. The size and appearance of this probe is similar to current commercially available transrectal imaging probes. Prostate ablation was successful in all dogs and no injury to the rectal wall was apparent when energy levels were appropriate. Again, the post ablation prostate resembled a TUR-P defect. The implications of these findings using this new modality are potentially immense. Plans for human trials are being formulated.

UR - http://www.scopus.com/inward/record.url?scp=0025790646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025790646&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0025790646

VL - 1421

SP - 47

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Watson, Grahm M

A2 - Steiner, Rudolf W.

A2 - Pietrafitta, Joseph J.

PB - Publ by Int Soc for Optical Engineering

ER -