Nonsurgical Approaches to Treat Biliary Tract and Liver Tumors

Benjamin L. Green, Michael G. House

Research output: Contribution to journalReview article

2 Scopus citations


Endoscopic and percutaneous therapies have been shown to prolong life and reduce morbidity for patients with unresectable advanced stages of primary hepatobiliary malignancies. This article reviews pertinent studies published within the last 5 years that involve locoregional techniques to manage hepatocellular carcinoma, perihilar and distal cholangiocarcinoma. A major emphasis is placed on photodynamic therapy, radiofrequency ablation, irreversible electroporation, and microwave ablation. Technical advances, combinational therapies, and postintervention outcomes are discussed. Despite widespread application, high-quality evidence does not show superiority of any particular locoregional technique for treating advanced hepatobiliary cancers.

Original languageEnglish (US)
Pages (from-to)573-586
Number of pages14
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - Oct 2019


  • Cholangiocarcinoma
  • Hepatocellular carcinoma
  • Microwave ablation
  • Photodynamic therapy
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Surgery
  • Oncology

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