Nontuberculous mycobacterial disease mortality in the United States, 1999-2010

A population-based comparative study

Mehdi Mirsaeidi, Roberto Machado, Joe G.N. Garcia, Dean E. Schraufnagel

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: Environmental nontuberculous mycobacteria (NTM) are ubiquitous organisms with which humans commonly interact. The epidemiologic characteristics of NTM diseases including mortality rate and its associated factors remain largely unknown. In this study, we explored the geographical area of exposure and mortality and comorbid conditions of affected persons to determine environment, host, and host-pathogen interactive factors. Methods: We analyzed mortality related to nontuberculous mycobacterial infections from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. Among those who died with these diseases, we analyzed age-adjusted mortality rates, trends, associations with demographic variables, and comorbid conditions and correlated this information with similar data for tuberculosis-related mortality during the same time. Measurements and Mean Results: From 1999 through 2010, nontuberculous mycobacterial disease was reported as an immediate cause of death in 2,990 people in the United States with a combined overall mean age-adjusted mortality rate of 0.1 per 100,000 person-years. A significant increase in the number of NTM related deaths was seen from 1999 through 2010 (R2 = 0.72, p<0.0001), but it was not significant after adjustment for age. Persons aged 55 years and older, women, those living in Hawaii and Louisiana, and those of non-Hispanic, white ethnicity had higher mortality rates. Compared to tuberculosis-related mortality, chronic obstructive pulmonary disease, bronchiectasis, HIV, interstitial lung diseases, and tobacco use were significantly more common in persons with nontuberculous mycobacteria-related deaths. Conclusions: Nontuberculous mycobacteria-related death numbers are rising and are unevenly distributed. The strong association of nontuberculous mycobacterial disease with age suggests that its prevalence will increase as the United States population ages.

Original languageEnglish (US)
Article numbere91879
JournalPLoS One
Volume9
Issue number3
DOIs
StatePublished - Mar 14 2014
Externally publishedYes

Fingerprint

mycobacterial diseases
Nontuberculous Mycobacteria
Mycobacterium
Pulmonary diseases
Mortality
Population
death
Tobacco
Pathogens
tuberculosis
respiratory tract diseases
Cause of Death
Tuberculosis
Health
Statistics
tobacco use
National Center for Health Statistics (U.S.)
Bronchiectasis
Interstitial Lung Diseases
Tobacco Use

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nontuberculous mycobacterial disease mortality in the United States, 1999-2010 : A population-based comparative study. / Mirsaeidi, Mehdi; Machado, Roberto; Garcia, Joe G.N.; Schraufnagel, Dean E.

In: PLoS One, Vol. 9, No. 3, e91879, 14.03.2014.

Research output: Contribution to journalArticle

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