Noradrenergic Function in Panic Anxiety

Effects of Yohimbine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder

Dennis S. Charney, George R. Heninger, Alan Breier

Research output: Contribution to journalArticle

485 Citations (Scopus)

Abstract

Yohimbine, an α2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 20 healthy subjects and 39 drug-free patients with agoraphobia and panic attacks. Following drug administration, changes in plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), BP, pulse rate, and subjective ratings of feelings and somatic symptoms were examined during a four-hour period. Yohimbine produced significantly greater increases in patient-rated anxiety, nervousness, palpitations, hot and cold flashes, restlessness, tremors, piloerection, and sitting systolic BP in the total patient group compared with healthy subjects. There were significant correlations between the yohimbine-induced rise in plasma MHPG level and patient-rated anxiety and nervousness and the frequency of reported panic attacks. Patients experiencing frequent panic attacks (&2.5 per week) had a significantly greater plasma MHPG response to yohimbine than the healthy subjects and patients having less frequent panic attacks. These observations support a hypothesis of increased sensitivity to augmented noradrenergic function in anxiety states associated with panic, and they suggest that impaired presynaptic noradrenergic neuronal regulation may exist in patients with frequent panic attacks.

Original languageEnglish (US)
Pages (from-to)751-763
Number of pages13
JournalArchives of General Psychiatry
Volume41
Issue number8
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Agoraphobia
Panic
Yohimbine
Panic Disorder
Healthy Volunteers
Anxiety
Piloerection
Hot Flashes
Psychomotor Agitation
Adrenergic Antagonists
Tremor
Pharmaceutical Preparations
Norepinephrine
Emotions
Heart Rate
Attack

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Noradrenergic Function in Panic Anxiety : Effects of Yohimbine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder. / Charney, Dennis S.; Heninger, George R.; Breier, Alan.

In: Archives of General Psychiatry, Vol. 41, No. 8, 1984, p. 751-763.

Research output: Contribution to journalArticle

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