Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome

Kieren Mather, Subodh Verma, Bernard Corenblum, Todd J. Anderson

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Women with the polycystic ovarian syndrome (PCOS) carry a number of cardiovascular risk factors, including insulin resistance, lipid abnormalities, and an altered pattern of sex steroid exposure. Non-invasive measurements of endothelial function, which can demonstrate abnormalities well in advance of clinically apparent disease, have not been previously reported in this patient group. We undertook a cross-sectional evaluation of endothelium-dependent and -independent vascular function using brachial artery ultrasound. We studied healthy women with clinical and laboratory evidence of PCOS (n = 18) and age-matched controls (n = 19), not taking any antihypertensive, cholesterol-lowering, or hormonal therapies. Laboratory parameters of insulin resistance, glycemia, cholesterol status, and hormone levels were also measured. Despite marked differences in glucose/insulin ratio [6.1 ± 1.1 mmol/pmol (PCOS) vs. 9.9 ± 0.6 (controls)] and free androgen index [11.9 ± 2.3 (PCOS) vs. 3.7 ± 0.6 (controls); normal,

Original languageEnglish (US)
Pages (from-to)1851-1856
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume85
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Polycystic Ovary Syndrome
Insulin Resistance
Insulin
Cholesterol
Antihypertensive Agents
Androgens
Brachial Artery
Ultrasonics
Steroids
Hormones
Endothelium
Blood Vessels
Lipids
Glucose
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome. / Mather, Kieren; Verma, Subodh; Corenblum, Bernard; Anderson, Todd J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 85, No. 5, 2000, p. 1851-1856.

Research output: Contribution to journalArticle

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