Normal rats trained to circle show asymmetric caudate dopamine release

Bryan Yamamoto, Ross F. Lane, Curt R. Freed

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Caudate catecholamine release was monitored by bilateral in vivo electrochemical electrodes in male Sprague-Dawley rats trained to circle for sucrose/water reward. Baseline release of dopamine was equal from both sides of caudate. When reinforced circling began, 33 ± 4 percent greater catechol release occured from the caudate contralateral to the circling direction. As turning subsided, differential release returned to basal levels. Further evidence that the catecholamine metabolism was affected by turning was obtained by direct measurement of caudate dopamine and DOPAC at selected time points. Concentration data showed relative increases in dopamine and DOPAC in the contralateral caudate. These data provide evidence that dopamine is released asymmetrically from caudate in unlesioned rats during voluntary behavior.

Original languageEnglish (US)
Pages (from-to)2155-2162
Number of pages8
JournalLife Sciences
Volume30
Issue number25
DOIs
StatePublished - Jun 21 1982
Externally publishedYes

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Rats
Dopamine
3,4-Dihydroxyphenylacetic Acid
Catecholamines
Electrochemical electrodes
Reward
Metabolism
Sprague Dawley Rats
Sucrose
Electrodes
Water

ASJC Scopus subject areas

  • Pharmacology

Cite this

Normal rats trained to circle show asymmetric caudate dopamine release. / Yamamoto, Bryan; Lane, Ross F.; Freed, Curt R.

In: Life Sciences, Vol. 30, No. 25, 21.06.1982, p. 2155-2162.

Research output: Contribution to journalArticle

Yamamoto, Bryan ; Lane, Ross F. ; Freed, Curt R. / Normal rats trained to circle show asymmetric caudate dopamine release. In: Life Sciences. 1982 ; Vol. 30, No. 25. pp. 2155-2162.
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