Notch signaling and bone remodeling

Jenna Regan, Fanxin Long

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalCurrent osteoporosis reports
Volume11
Issue number2
DOIs
StatePublished - Jun 1 2013

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Keywords

  • Alagille syndrome
  • Bone remodeling
  • Hajdu-Cheney syndrome
  • Notch signaling
  • Osteoblasts
  • Osteoclasts
  • Skeletal development
  • Skeletal diseases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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