Novel approach to outpatient endometrial biopsy to detect endometrial cancer

Maria C B de Leon, Howard Wu, Ashley E. Lennon, Giuseppe del Priore

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To evaluate a new device for obtaining endometrial biopsies which combines global endometrial disruption using a brush with a built-in suction process. STUDY DESIGN: Endometrial biopsies were collected, using the GDP-Tao device, from fresh uteri hysterectomy specimens after completion of surgery. Results were compared to final hysterectomy pathology. Specificity and sensitivity and positive and negative predictive values were calculated. RESULTS: Based on a sample size calculation, 42 patients were included in this study. Endometrial tissue adequate for diagnosis was obtained in 93% (39/42) of biopsies. Classifying atypia as a positive result, the sensitivity of the new device was 96% (23/24), with specificity of 87% (13/15). The positive predictive value was 92% (23/25) and the negative predictive value, 93% (13/14). There were 2 nondiagnostic (ND) samples from GDP-Tao with final pathology of benign endometrium. One specimen was ND on both GDP-Tao and final pathology due to absence of tissue after prior endometrial ablation. When stratified by uterine size, benign or malignant, the results were similar. CONCLUSION: Our validation study showed encouraging results for the GDP-Tao, which combines tissue disruption and aspiration into a single process. The device provides a reliable means of obtaining adequate samples to accurately detect endometrial cancer with a high negative and positive predictive value.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume61
Issue number3
StatePublished - Jun 1 2016

Fingerprint

Endometrial Neoplasms
Outpatients
Biopsy
Equipment and Supplies
Pathology
Hysterectomy
Endometrial Ablation Techniques
Validation Studies
Suction
Endometrium
Sample Size
Uterus
Sensitivity and Specificity

Keywords

  • Biopsy
  • Cancer of the uterus
  • Cancer screening
  • Cancer screening tests
  • Cytopathology
  • Early diagnosis of cancer
  • Endometrial biopsy
  • Endometrial cancer
  • Endometrial neoplasms
  • Histopathology
  • Medical devices
  • Pathology
  • Uterine cancer
  • Uterine neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Novel approach to outpatient endometrial biopsy to detect endometrial cancer. / de Leon, Maria C B; Wu, Howard; Lennon, Ashley E.; del Priore, Giuseppe.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 61, No. 3, 01.06.2016, p. 243-248.

Research output: Contribution to journalArticle

de Leon, Maria C B ; Wu, Howard ; Lennon, Ashley E. ; del Priore, Giuseppe. / Novel approach to outpatient endometrial biopsy to detect endometrial cancer. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2016 ; Vol. 61, No. 3. pp. 243-248.
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abstract = "OBJECTIVE: To evaluate a new device for obtaining endometrial biopsies which combines global endometrial disruption using a brush with a built-in suction process. STUDY DESIGN: Endometrial biopsies were collected, using the GDP-Tao device, from fresh uteri hysterectomy specimens after completion of surgery. Results were compared to final hysterectomy pathology. Specificity and sensitivity and positive and negative predictive values were calculated. RESULTS: Based on a sample size calculation, 42 patients were included in this study. Endometrial tissue adequate for diagnosis was obtained in 93{\%} (39/42) of biopsies. Classifying atypia as a positive result, the sensitivity of the new device was 96{\%} (23/24), with specificity of 87{\%} (13/15). The positive predictive value was 92{\%} (23/25) and the negative predictive value, 93{\%} (13/14). There were 2 nondiagnostic (ND) samples from GDP-Tao with final pathology of benign endometrium. One specimen was ND on both GDP-Tao and final pathology due to absence of tissue after prior endometrial ablation. When stratified by uterine size, benign or malignant, the results were similar. CONCLUSION: Our validation study showed encouraging results for the GDP-Tao, which combines tissue disruption and aspiration into a single process. The device provides a reliable means of obtaining adequate samples to accurately detect endometrial cancer with a high negative and positive predictive value.",
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