Novel Approach to Outpatient Endometrial Biopsy to Detect Endometrial Cancer

Maria C B de Leon, Howard H. Wu, Ashley E. Lennon, Giuseppe Del Priore

Research output: Contribution to journalArticle

Abstract

RESULTS: Based on a sample size calculation, 42 patients were included in this study. Endometrial tissue adequate for diagnosis was obtained in 93% (39/42) of biopsies. Classifying atypia as a positive result, the sensitivity of the new device was 96% (23/24), with specificity of 87% (13/15). The positive predictive value was 92% (23/25) and the negative predictive value, 93% (13/14). There were 2 nondiagnostic (ND) samples from GDP-Tao with final pathology of benign endometrium. One specimen was ND on both GDP-Tao and final pathology due to absence of tissue after prior endometrial ablation. When stratified by uterine size, benign or malignant, the results were similar.

CONCLUSION: Our validation study showed encouraging results for the GDP-Tao, which combines tissue disruption and aspiration into a single process. The device provides a reliable means of obtaining adequate samples to accurately detect endometrial cancer with a high negative and positive predictive value.

OBJECTIVE: To evaluate a new device for obtaining endometrial biopsies which combines global endometrial disruption using a brush with a built-in suction process.

STUDY DESIGN: Endometrial biopsies were collected, using the GDP-Tao device, from fresh uteri hysterectomy specimens after completion of surgery. Results were compared to final hysterectomy pathology. Specificity and sensitivity and positive and negative predictive values were calculated.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalThe Journal of reproductive medicine
Volume61
Issue number5-6
StatePublished - May 1 2016
Externally publishedYes

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Endometrial Neoplasms
Outpatients
Biopsy
Equipment and Supplies
Pathology
Hysterectomy
Endometrial Ablation Techniques
Validation Studies
Suction
Endometrium
Sample Size
Uterus
Sensitivity and Specificity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Novel Approach to Outpatient Endometrial Biopsy to Detect Endometrial Cancer. / de Leon, Maria C B; Wu, Howard H.; Lennon, Ashley E.; Del Priore, Giuseppe.

In: The Journal of reproductive medicine, Vol. 61, No. 5-6, 01.05.2016, p. 243-248.

Research output: Contribution to journalArticle

de Leon, MCB, Wu, HH, Lennon, AE & Del Priore, G 2016, 'Novel Approach to Outpatient Endometrial Biopsy to Detect Endometrial Cancer', The Journal of reproductive medicine, vol. 61, no. 5-6, pp. 243-248.
de Leon, Maria C B ; Wu, Howard H. ; Lennon, Ashley E. ; Del Priore, Giuseppe. / Novel Approach to Outpatient Endometrial Biopsy to Detect Endometrial Cancer. In: The Journal of reproductive medicine. 2016 ; Vol. 61, No. 5-6. pp. 243-248.
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