Novel cancer therapies targeting angiogenesis

Monte Willis, Nancy Klauber-DeMore

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cancer growth is generally restricted to tissue that is approximately 2 mm in diameter. At this size, the cancer receives enough oxygen and nutrients by diffusion from nearby blood vessels to survive. Upon further growth, the proliferation of cells within the cancer is matched by the induction of apoptosis due to nutrient deprivation, resulting in a steady-state size. The way cancers adapt to these physical limits is by obtaining their own new blood supply. Only through the induction of its own blood supply, generally by the process of angiogenesis, can cancers exceed the 2 mm size limit and can continue to grow virtually unchecked. Cancer cells stimulate angiogenesis by secreting soluble factors that stimulate vessel growth and/or by suppressing factors that prevent angiogenesis. These factors act primarily upon endothelial cells to promote their proliferation and migration, resulting in the sprouting and formation of tubes, which then develop into vessels.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Number of pages6
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
StatePublished - Jan 1 2016
Externally publishedYes


  • Angiogenesis
  • Cancer progression
  • Growth factors
  • Novel cancer therapies
  • Receptor tyrosine kinases

ASJC Scopus subject areas

  • Medicine(all)

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