Novel developmental pathway regulation mechanisms of pten expression: Implications for human disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Phosphatase and Tensin homologue (PTEN) is the key endogenous negative modulator of phosphoinoside signaling in mammalian cells. By dephosphorylating phosphoinositide trisphosphate (PIP3), PTEN has the function of turning off Akt, thereby inhibiting this key intracellular signal transduction pathway. Loss-of-function mutations in PTEN therefore have the effect of leaving Akt signaling unopposed. While much has been described regarding mutations in PTEN leading to unregulated Akt and human disease, most notably cancer, less is known about intrinsic regulation of PTEN. In this chapter, we review a recently emergent literature on PTEN transcriptional, post-transcriptional, translational, and post-translational regulation. This chapter focuses on the role developmental signaling pathways play in PTEN regulation, including insulin-like growth factor, NOTCH, transforming growth factor, bone morphogenetic protein, wnt, and hedgehog signaling. Developmental mediator regulation of PTEN affects critical biological processes including neuronal and organ development, stem cell maintenance, cell cycle regulation, inflammation, response to hypoxia, repair and recovery, and cell death and survival. Disruption of PTEN regulation can therefore lead to human diseases including cancer, chronic inflammatory syndromes, developmental defects, diabetes, and necrosis.

Original languageEnglish (US)
Title of host publicationPTEN
Subtitle of host publicationStructure, Mechanisms-of-Action, Role in Cell Signaling and Regulation
PublisherNova Science Publishers, Inc.
Pages79-99
Number of pages21
ISBN (Print)9781628080490
StatePublished - Dec 1 2013

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Keywords

  • Developmental biology
  • Developmental signaling
  • PTEN
  • Regulation
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jerde, T. J. (2013). Novel developmental pathway regulation mechanisms of pten expression: Implications for human disease. In PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation (pp. 79-99). Nova Science Publishers, Inc..