Novel expression of the goosecoid transcription factor in the embryonic mouse heart

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Goosecoid (gsc) is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalMechanisms of Development
Volume81
Issue number1-2
DOIs
StatePublished - Mar 1 1999
Externally publishedYes

Keywords

  • Goosecoid
  • Heart
  • Mouse
  • Neural crest
  • Outflow tract

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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