Novel expression of the goosecoid transcription factor in the embryonic mouse heart

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Goosecoid (gsc) is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalMechanisms of Development
Volume81
Issue number1-2
DOIs
StatePublished - Mar 1 1999
Externally publishedYes

Fingerprint

Goosecoid Protein
Gastrulation
Morphogenesis
In Situ Hybridization
Vertebrates
Embryonic Structures

Keywords

  • Goosecoid
  • Heart
  • Mouse
  • Neural crest
  • Outflow tract

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Novel expression of the goosecoid transcription factor in the embryonic mouse heart. / Conway, Simon.

In: Mechanisms of Development, Vol. 81, No. 1-2, 01.03.1999, p. 187-191.

Research output: Contribution to journalArticle

@article{dec446f638824b99a8c38e8accf5d495,
title = "Novel expression of the goosecoid transcription factor in the embryonic mouse heart",
abstract = "Goosecoid (gsc) is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart.",
keywords = "Goosecoid, Heart, Mouse, Neural crest, Outflow tract",
author = "Simon Conway",
year = "1999",
month = "3",
day = "1",
doi = "10.1016/S0925-4773(98)00235-4",
language = "English (US)",
volume = "81",
pages = "187--191",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Novel expression of the goosecoid transcription factor in the embryonic mouse heart

AU - Conway, Simon

PY - 1999/3/1

Y1 - 1999/3/1

N2 - Goosecoid (gsc) is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart.

AB - Goosecoid (gsc) is expressed in the organizer region of vertebrate embryos undergoing the movements of gastrulation. Likewise, the early heart tube (8.5-9.5 dpc) undergoes a similar process of looping to bring the atrial region cranial and dorsal to the ventricular region, eventually giving rise to the four chambered heart. In order to determine whether gsc is similarly involved in heart morphogenesis, in situ hybridization and RT-PCR were used to detect gsc expression in the embryonic mouse heart. We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart.

KW - Goosecoid

KW - Heart

KW - Mouse

KW - Neural crest

KW - Outflow tract

UR - http://www.scopus.com/inward/record.url?scp=0032915567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032915567&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(98)00235-4

DO - 10.1016/S0925-4773(98)00235-4

M3 - Article

C2 - 10330498

AN - SCOPUS:0032915567

VL - 81

SP - 187

EP - 191

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 1-2

ER -