Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion

Ítallo Emídio Lira Viana, Raquel Marianna Lopes, Flávia Rodrigues Oliveira Silva, Nelson Batista Lima, Ana Cecília Corrêa Aranha, Sabrina Feitosa, Taís Scaramucci

Research output: Contribution to journalArticle


Objective: To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin. Methods: β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n = 10): Control (water); F (NaF, 225 ppm F); F + Sn (NaF + SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-TCP); F + Sn+β-TCP (F + Sn+40 ppm β-TCP); F + Sn+100β-TCP (F + Sn+100 ppm β-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss (SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey's tests (α = 0.05). Results: XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F + Sn+β-TCP, and F + Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups. Conclusion: β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with fluoride plus stannous in both substrates. Clinical Relevance: β-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion.

Original languageEnglish (US)
Article number103263
JournalJournal of Dentistry
StatePublished - Jan 2020


  • Dentin
  • Enamel
  • Fluoride
  • Stannous
  • Tooth erosion
  • β-TCP nanoparticles

ASJC Scopus subject areas

  • Dentistry(all)

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