Novel functions of circulating Klotho

Julia M. Hum, Linda O'Bryan, Rosamund C. Smith, Kenneth White

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implications for common disorders such as chronic kidney disease-mineral bone disorder (CKD-MBD). αKL's predominant effect on mineral homeostasis is through its actions in the kidney as a co-receptor for FGF23, however emerging data has shed light on its capacity to act as a circulating factor through the cleavage of the transmembrane form of αKL ('mKL') to produce 'cleaved KL' or 'cKL'. This review summarizes new findings from studies using extended delivery of cKL to mouse models with phenotypes reflecting those arising in CKD-MBD.

Original languageEnglish (US)
JournalBone
DOIs
StateAccepted/In press - Oct 23 2016

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
Minerals
Rare Diseases
Homeostasis
Ligands
Phenotype
Kidney
fibroblast growth factor 23

Keywords

  • CKL
  • FGF23
  • Hyperphosphatemia
  • Hypophosphatemia
  • Phosphate
  • Vascular calcification

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Physiology

Cite this

Novel functions of circulating Klotho. / Hum, Julia M.; O'Bryan, Linda; Smith, Rosamund C.; White, Kenneth.

In: Bone, 23.10.2016.

Research output: Contribution to journalArticle

Hum, Julia M. ; O'Bryan, Linda ; Smith, Rosamund C. ; White, Kenneth. / Novel functions of circulating Klotho. In: Bone. 2016.
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