Novel functions of circulating Klotho

Julia M. Hum, Linda O'Bryan, Rosamund C. Smith, Kenneth E. White

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implications for common disorders such as chronic kidney disease-mineral bone disorder (CKD-MBD). αKL's predominant effect on mineral homeostasis is through its actions in the kidney as a co-receptor for FGF23, however emerging data has shed light on its capacity to act as a circulating factor through the cleavage of the transmembrane form of αKL (‘mKL’) to produce ‘cleaved KL’ or ‘cKL’. This review summarizes new findings from studies using extended delivery of cKL to mouse models with phenotypes reflecting those arising in CKD-MBD.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalBone
Volume100
DOIs
StatePublished - Jul 2017

Keywords

  • FGF23
  • Hyperphosphatemia
  • Hypophosphatemia
  • Phosphate
  • Vascular calcification
  • cKL

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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