Novel gastric sleeve magnetic implant: safety and efficacy in rats

Xiaomei Guo, Samer Mattar, Celina Morales, Jose A. Navia, Ghassan S. Kassab

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The prevalence of obesity is growing worldwide and has reached epidemic proportions. Vertical sleeve gastrectomy, which requires irreversible removal of gastric tissue, is considered an effective weight loss treatment of severe obesity. The aim of the present study was to evaluate the feasibility of a reversible gastric sleeve magnetic implant that mimics the vertical sleeve gastrectomy without the gastrectomy for weight loss in a group of normal and obese rats. Methods: A group of Zucker fatty rats either underwent surgical implantation or a sham operation and were followed up for 6 weeks. Also, a group of Wistar rats underwent surgical implantation for 6 weeks, followed by surgical implant removal at 6 weeks, and recovery for an additional 4 weeks. Food intake and body weight were monitored after surgery to determine the efficacy of the device. A histologic examination for all rats was made to evaluate the change in the gastric wall in response to gastric sleeve magnetic implantation. Results: The implanted Zucker fatty and Wistar rats showed a statistically significant decrease in food intake and weight gain rate compared with the sham-operated rats (approximately 3%/wk of body weight loss in the treated group). Moreover, the decrease in the weight gain rate was sustained for 4 weeks after removal of the magnetic implant. The histologic evidence revealed an inflammatory mononuclear cell infiltration and mild fibrosis and hyperplasia of blood vessels, as expected for any implant. No significant structural damage, tissue ischemia, hemorrhage, or necrosis was found in the gastric wall. Conclusion: Our results have shown that the device is feasible in rats, results in effective weight loss, and can be easily removed. These findings, along with the lack of the need for resection of the native stomach, provide a compelling basis for additional development of the device in large animal models.

Original languageEnglish
Pages (from-to)684-691
Number of pages8
JournalSurgery for Obesity and Related Diseases
Volume5
Issue number6
DOIs
StatePublished - Nov 2009

Fingerprint

Stomach
Safety
Weight Loss
Gastrectomy
Zucker Rats
Equipment and Supplies
Weight Gain
Wistar Rats
Eating
Body Weight
Morbid Obesity
Hyperplasia
Blood Vessels
Fibrosis
Necrosis
Ischemia
Animal Models
Obesity
Hemorrhage

Keywords

  • Body weight
  • Food intake
  • Magnetic implant
  • Obesity
  • Vertical sleeve gastrectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Novel gastric sleeve magnetic implant : safety and efficacy in rats. / Guo, Xiaomei; Mattar, Samer; Morales, Celina; Navia, Jose A.; Kassab, Ghassan S.

In: Surgery for Obesity and Related Diseases, Vol. 5, No. 6, 11.2009, p. 684-691.

Research output: Contribution to journalArticle

Guo, Xiaomei ; Mattar, Samer ; Morales, Celina ; Navia, Jose A. ; Kassab, Ghassan S. / Novel gastric sleeve magnetic implant : safety and efficacy in rats. In: Surgery for Obesity and Related Diseases. 2009 ; Vol. 5, No. 6. pp. 684-691.
@article{09a04b2e982f4449916a037a301b71fe,
title = "Novel gastric sleeve magnetic implant: safety and efficacy in rats",
abstract = "Background: The prevalence of obesity is growing worldwide and has reached epidemic proportions. Vertical sleeve gastrectomy, which requires irreversible removal of gastric tissue, is considered an effective weight loss treatment of severe obesity. The aim of the present study was to evaluate the feasibility of a reversible gastric sleeve magnetic implant that mimics the vertical sleeve gastrectomy without the gastrectomy for weight loss in a group of normal and obese rats. Methods: A group of Zucker fatty rats either underwent surgical implantation or a sham operation and were followed up for 6 weeks. Also, a group of Wistar rats underwent surgical implantation for 6 weeks, followed by surgical implant removal at 6 weeks, and recovery for an additional 4 weeks. Food intake and body weight were monitored after surgery to determine the efficacy of the device. A histologic examination for all rats was made to evaluate the change in the gastric wall in response to gastric sleeve magnetic implantation. Results: The implanted Zucker fatty and Wistar rats showed a statistically significant decrease in food intake and weight gain rate compared with the sham-operated rats (approximately 3{\%}/wk of body weight loss in the treated group). Moreover, the decrease in the weight gain rate was sustained for 4 weeks after removal of the magnetic implant. The histologic evidence revealed an inflammatory mononuclear cell infiltration and mild fibrosis and hyperplasia of blood vessels, as expected for any implant. No significant structural damage, tissue ischemia, hemorrhage, or necrosis was found in the gastric wall. Conclusion: Our results have shown that the device is feasible in rats, results in effective weight loss, and can be easily removed. These findings, along with the lack of the need for resection of the native stomach, provide a compelling basis for additional development of the device in large animal models.",
keywords = "Body weight, Food intake, Magnetic implant, Obesity, Vertical sleeve gastrectomy",
author = "Xiaomei Guo and Samer Mattar and Celina Morales and Navia, {Jose A.} and Kassab, {Ghassan S.}",
year = "2009",
month = "11",
doi = "10.1016/j.soard.2009.07.005",
language = "English",
volume = "5",
pages = "684--691",
journal = "Surgery for Obesity and Related Diseases",
issn = "1550-7289",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Novel gastric sleeve magnetic implant

T2 - safety and efficacy in rats

AU - Guo, Xiaomei

AU - Mattar, Samer

AU - Morales, Celina

AU - Navia, Jose A.

AU - Kassab, Ghassan S.

PY - 2009/11

Y1 - 2009/11

N2 - Background: The prevalence of obesity is growing worldwide and has reached epidemic proportions. Vertical sleeve gastrectomy, which requires irreversible removal of gastric tissue, is considered an effective weight loss treatment of severe obesity. The aim of the present study was to evaluate the feasibility of a reversible gastric sleeve magnetic implant that mimics the vertical sleeve gastrectomy without the gastrectomy for weight loss in a group of normal and obese rats. Methods: A group of Zucker fatty rats either underwent surgical implantation or a sham operation and were followed up for 6 weeks. Also, a group of Wistar rats underwent surgical implantation for 6 weeks, followed by surgical implant removal at 6 weeks, and recovery for an additional 4 weeks. Food intake and body weight were monitored after surgery to determine the efficacy of the device. A histologic examination for all rats was made to evaluate the change in the gastric wall in response to gastric sleeve magnetic implantation. Results: The implanted Zucker fatty and Wistar rats showed a statistically significant decrease in food intake and weight gain rate compared with the sham-operated rats (approximately 3%/wk of body weight loss in the treated group). Moreover, the decrease in the weight gain rate was sustained for 4 weeks after removal of the magnetic implant. The histologic evidence revealed an inflammatory mononuclear cell infiltration and mild fibrosis and hyperplasia of blood vessels, as expected for any implant. No significant structural damage, tissue ischemia, hemorrhage, or necrosis was found in the gastric wall. Conclusion: Our results have shown that the device is feasible in rats, results in effective weight loss, and can be easily removed. These findings, along with the lack of the need for resection of the native stomach, provide a compelling basis for additional development of the device in large animal models.

AB - Background: The prevalence of obesity is growing worldwide and has reached epidemic proportions. Vertical sleeve gastrectomy, which requires irreversible removal of gastric tissue, is considered an effective weight loss treatment of severe obesity. The aim of the present study was to evaluate the feasibility of a reversible gastric sleeve magnetic implant that mimics the vertical sleeve gastrectomy without the gastrectomy for weight loss in a group of normal and obese rats. Methods: A group of Zucker fatty rats either underwent surgical implantation or a sham operation and were followed up for 6 weeks. Also, a group of Wistar rats underwent surgical implantation for 6 weeks, followed by surgical implant removal at 6 weeks, and recovery for an additional 4 weeks. Food intake and body weight were monitored after surgery to determine the efficacy of the device. A histologic examination for all rats was made to evaluate the change in the gastric wall in response to gastric sleeve magnetic implantation. Results: The implanted Zucker fatty and Wistar rats showed a statistically significant decrease in food intake and weight gain rate compared with the sham-operated rats (approximately 3%/wk of body weight loss in the treated group). Moreover, the decrease in the weight gain rate was sustained for 4 weeks after removal of the magnetic implant. The histologic evidence revealed an inflammatory mononuclear cell infiltration and mild fibrosis and hyperplasia of blood vessels, as expected for any implant. No significant structural damage, tissue ischemia, hemorrhage, or necrosis was found in the gastric wall. Conclusion: Our results have shown that the device is feasible in rats, results in effective weight loss, and can be easily removed. These findings, along with the lack of the need for resection of the native stomach, provide a compelling basis for additional development of the device in large animal models.

KW - Body weight

KW - Food intake

KW - Magnetic implant

KW - Obesity

KW - Vertical sleeve gastrectomy

UR - http://www.scopus.com/inward/record.url?scp=70450228683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70450228683&partnerID=8YFLogxK

U2 - 10.1016/j.soard.2009.07.005

DO - 10.1016/j.soard.2009.07.005

M3 - Article

C2 - 19796998

AN - SCOPUS:70450228683

VL - 5

SP - 684

EP - 691

JO - Surgery for Obesity and Related Diseases

JF - Surgery for Obesity and Related Diseases

SN - 1550-7289

IS - 6

ER -