Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas

Claire M. Mach, Jong Kim, Benjamin Soibam, Chad J. Creighton, Shannon M. Hawkins, Israel Zighelboim, Paul Goodfellow, Preethi H. Gunaratne, Kunle Odunsi, Philip A. Salem, Matthew L. Anderson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

MicroRNAs (miRNAs) are endogenous, non-coding RNA transcripts that regulate gene expression. Here, we report 175 putative novel miRNAs identified in uterine cancers profiled by Next Generation Sequencing. Our data indicate that one of these putative miRNAs (BCM-173) is conserved across multiple species and is expressed at levels similar to known human miRNAs. Functionally, this miRNA promotes the growth and migration of uterine cancer cell lines by targeting vinculin and altering the distribution of focal adhesions. These results expand our insight into the repertoire of human miRNAs and identify novel pathways by which dysregulated miRNA expression promotes uterine cancer growth.

Original languageEnglish (US)
Pages (from-to)314-322
Number of pages9
JournalCancer Letters
Volume335
Issue number2
DOIs
StatePublished - Jul 28 2013
Externally publishedYes

Keywords

  • Focal adhesions
  • MicroRNA
  • Migration
  • Uterine cancer
  • Vinculin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Mach, C. M., Kim, J., Soibam, B., Creighton, C. J., Hawkins, S. M., Zighelboim, I., Goodfellow, P., Gunaratne, P. H., Odunsi, K., Salem, P. A., & Anderson, M. L. (2013). Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas. Cancer Letters, 335(2), 314-322. https://doi.org/10.1016/j.canlet.2013.02.043