Novel ocular lubricant containing an intelligent delivery system

Details of its mechanism of action

Clark Springs

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Objective: The purpose of this review is to outline the mechanism of action of a novel ocular lubricant incorporating hydroxypropyl-guar (HPG) and the demulcents polyethylene glycol 400 and propylene glycol. Methods: The literature relating to the mechanism of action of Systane Ultra is presented. The literature search covered the period prior to June 2008. A manual search was also conducted based on citations in the published literature. Additional original reports were referenced if relevant to the subject matter of the review. Results and Conclusion: The published literature supports the efficacy of an ocular lubricant containing HPG at reducing the signs and symptoms of dry eye through its multiphasic behavior and duration of action. This new formulation presents an additional benefit of a delivery system to further reduce the assimilation time of the product on-eye. Beneficial outcomes have been documented for tear film interaction, blur profile, viscoelasticity and tensile strength.

Original languageEnglish (US)
Title of host publicationResearch Projects in Dry Eye Syndrome
PublisherS. Karger AG
Pages139-147
Number of pages9
Volume45
ISBN (Print)9783805594196, 9783805594189
DOIs
StatePublished - May 11 2010

Fingerprint

Lubricants
lubricants
mechanism of action
eyes
viscoelasticity
Propylene Glycol
propylene glycol
Tensile Strength
tensile strength
polyethylene glycol
Tears
films (materials)
Signs and Symptoms
duration
hydroxypropyl guar

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • veterinary(all)

Cite this

Springs, C. (2010). Novel ocular lubricant containing an intelligent delivery system: Details of its mechanism of action. In Research Projects in Dry Eye Syndrome (Vol. 45, pp. 139-147). S. Karger AG. https://doi.org/10.1159/000315027

Novel ocular lubricant containing an intelligent delivery system : Details of its mechanism of action. / Springs, Clark.

Research Projects in Dry Eye Syndrome. Vol. 45 S. Karger AG, 2010. p. 139-147.

Research output: Chapter in Book/Report/Conference proceedingChapter

Springs, C 2010, Novel ocular lubricant containing an intelligent delivery system: Details of its mechanism of action. in Research Projects in Dry Eye Syndrome. vol. 45, S. Karger AG, pp. 139-147. https://doi.org/10.1159/000315027
Springs C. Novel ocular lubricant containing an intelligent delivery system: Details of its mechanism of action. In Research Projects in Dry Eye Syndrome. Vol. 45. S. Karger AG. 2010. p. 139-147 https://doi.org/10.1159/000315027
Springs, Clark. / Novel ocular lubricant containing an intelligent delivery system : Details of its mechanism of action. Research Projects in Dry Eye Syndrome. Vol. 45 S. Karger AG, 2010. pp. 139-147
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