Novel peptidomimetic hematoregulatory compounds

Dirk A. Heerding, Melanie Abruzzese, Doreen Alberts, Joelle Burgess, James F. Callahan, William F. Huffman, Andrew G. King, Stephen Locastro, Peter Demarsh, Louis M. Pelus, Joanne S. Takata, Pradip K. Bhatnagar

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Abstract

The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure-activity relationships of a peptide SK and F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number6
DOIs
StatePublished - Mar 20 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Heerding, D. A., Abruzzese, M., Alberts, D., Burgess, J., Callahan, J. F., Huffman, W. F., King, A. G., Locastro, S., Demarsh, P., Pelus, L. M., Takata, J. S., & Bhatnagar, P. K. (2000). Novel peptidomimetic hematoregulatory compounds. Bioorganic and Medicinal Chemistry Letters, 10(6), 531-534. https://doi.org/10.1016/S0960-894X(00)00036-6