Novel peptidomimetic hematoregulatory compounds

Dirk A. Heerding, Melanie Abruzzese, Doreen Alberts, Joelle Burgess, James F. Callahan, William F. Huffman, Andrew G. King, Stephen Locastro, Peter Demarsh, Louis Pelus, Joanne S. Takata, Pradip K. Bhatnagar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure-activity relationships of a peptide SK and F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number6
DOIs
StatePublished - Mar 20 2000
Externally publishedYes

Fingerprint

Peptidomimetics
Structure-Activity Relationship
Peptides
Therapeutics
SK&F 107647
peptide F

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Heerding, D. A., Abruzzese, M., Alberts, D., Burgess, J., Callahan, J. F., Huffman, W. F., ... Bhatnagar, P. K. (2000). Novel peptidomimetic hematoregulatory compounds. Bioorganic and Medicinal Chemistry Letters, 10(6), 531-534. https://doi.org/10.1016/S0960-894X(00)00036-6

Novel peptidomimetic hematoregulatory compounds. / Heerding, Dirk A.; Abruzzese, Melanie; Alberts, Doreen; Burgess, Joelle; Callahan, James F.; Huffman, William F.; King, Andrew G.; Locastro, Stephen; Demarsh, Peter; Pelus, Louis; Takata, Joanne S.; Bhatnagar, Pradip K.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 6, 20.03.2000, p. 531-534.

Research output: Contribution to journalArticle

Heerding, DA, Abruzzese, M, Alberts, D, Burgess, J, Callahan, JF, Huffman, WF, King, AG, Locastro, S, Demarsh, P, Pelus, L, Takata, JS & Bhatnagar, PK 2000, 'Novel peptidomimetic hematoregulatory compounds', Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 6, pp. 531-534. https://doi.org/10.1016/S0960-894X(00)00036-6
Heerding DA, Abruzzese M, Alberts D, Burgess J, Callahan JF, Huffman WF et al. Novel peptidomimetic hematoregulatory compounds. Bioorganic and Medicinal Chemistry Letters. 2000 Mar 20;10(6):531-534. https://doi.org/10.1016/S0960-894X(00)00036-6
Heerding, Dirk A. ; Abruzzese, Melanie ; Alberts, Doreen ; Burgess, Joelle ; Callahan, James F. ; Huffman, William F. ; King, Andrew G. ; Locastro, Stephen ; Demarsh, Peter ; Pelus, Louis ; Takata, Joanne S. ; Bhatnagar, Pradip K. / Novel peptidomimetic hematoregulatory compounds. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 6. pp. 531-534.
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