Novel peptidomimetic hematoregulatory compounds

Dirk A. Heerding, Melanie Abruzzese, Doreen Alberts, Joelle Burgess, James F. Callahan, William F. Huffman, Andrew G. King, Stephen Locastro, Peter Demarsh, Louis M. Pelus, Joanne S. Takata, Pradip K. Bhatnagar

Research output: Contribution to journalArticle

1 Scopus citations


The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure-activity relationships of a peptide SK and F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
StatePublished - Mar 20 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Heerding, D. A., Abruzzese, M., Alberts, D., Burgess, J., Callahan, J. F., Huffman, W. F., King, A. G., Locastro, S., Demarsh, P., Pelus, L. M., Takata, J. S., & Bhatnagar, P. K. (2000). Novel peptidomimetic hematoregulatory compounds. Bioorganic and Medicinal Chemistry Letters, 10(6), 531-534.