Novel recruitment strategy to enrich for lrrk2 mutation carriers

Tatiana Foroud, Danielle Smith, Jacqueline Jackson, Jennifer Verbrugge, Cheryl Halter, Leah Wetherill, Katherine Sims, Winnie Xin, Vanessa Arnedo, Shirley Lasch, Kenneth Marek

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The LRRK2 G2019S mutation is found at higher frequency among Parkinson disease (PD) patients of Ashkenazi Jewish (AJ) ancestry. This study was designed to test whether an internet-based approach could be an effective approach to screen and identify mutation carriers. Individuals with and without PD of AJ ancestry were recruited and consented through an internet-based study website. An algorithm was applied to a series of screening questions to identify individuals at increased risk to carry the LRRK2 G2019S mutation. About 1000 individuals completed the initial screening. Around 741 qualified for mutation testing and 650 were tested. Seventy-two individuals carried at least one LRRK2 G2019S mutation; 38 with PD (12.5%) and 34 without (10.1%). Among the AJ PD participants, each affected first-degree relative increased the likelihood the individual was LRRK2+ [OR = 4.7; 95% confidence interval = (2.4–9.0)]. The same was not observed among the unaffected AJ subjects (P = 0.11). An internet-based approach successfully screened large numbers of individuals to identify those with risk factors increasing the likelihood that they carried a LRRK2 G2019S mutation. A similar approach could be implemented in other disorders to identify individuals for clinical trials, biomarker analyses and other types of research studies.

Original languageEnglish (US)
Pages (from-to)404-412
Number of pages9
JournalMolecular Genetics and Genomic Medicine
Volume3
Issue number5
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Genetic testing
  • LRRK2
  • Parkinson disease

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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  • Cite this

    Foroud, T., Smith, D., Jackson, J., Verbrugge, J., Halter, C., Wetherill, L., Sims, K., Xin, W., Arnedo, V., Lasch, S., & Marek, K. (2015). Novel recruitment strategy to enrich for lrrk2 mutation carriers. Molecular Genetics and Genomic Medicine, 3(5), 404-412. https://doi.org/10.1002/mgg3.151