Novel roles for mucin 1 in the kidney

Mohammad M. Al-Bataineh, Timothy A. Sutton, Rebecca P. Hughey

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Purpose of review Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney. Recent findings Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes. It was recently reported that the TRPV5 calcium channel is stabilized on the cell surface by galectin-dependent cross-linking to mucin 1, providing a novel mechanism for regulation of ion channels and normal electrolyte balance. Our recent studies in mice show that Muc 1 is induced after ischemia, stabilizing hypoxia-inducible factor 1 (HIF-1)α and β-catenin levels, and transactivating the HIF-1 and β-catenin protective pathways. However, prolonged induction of either pathway in the injured kidney can proceed from apparent full recovery to chronic kidney disease. A very recent report indicates that aberrant activation of mucin 1 signaling after ischemic injury in mice and humans is associated with development of chronic kidney disease and fibrosis. A frameshift mutation in MUC1 was recently identified as the genetic lesion causing medullary cystic kidney disease type 1, now appropriately renamed MUC1 Kidney Disease. Summary Studies of mucin 1 in the kidney now reveal significant functions for the extracellular mucin-like domain and signaling through the cytoplasmic tail.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2017

Keywords

  • MUC1 Kidney Disease
  • TRPV5
  • acute kidney injury
  • chronic kidney disease
  • inflammation
  • mucin 1

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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