Novel roles for mucin 1 in the kidney

Mohammad M. Al-Bataineh, Timothy Sutton, Rebecca P. Hughey

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose of review Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney. Recent findings Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes. It was recently reported that the TRPV5 calcium channel is stabilized on the cell surface by galectin-dependent cross-linking to mucin 1, providing a novel mechanism for regulation of ion channels and normal electrolyte balance. Our recent studies in mice show that Muc 1 is induced after ischemia, stabilizing hypoxia-inducible factor 1 (HIF-1)α and β-catenin levels, and transactivating the HIF-1 and β-catenin protective pathways. However, prolonged induction of either pathway in the injured kidney can proceed from apparent full recovery to chronic kidney disease. A very recent report indicates that aberrant activation of mucin 1 signaling after ischemic injury in mice and humans is associated with development of chronic kidney disease and fibrosis. A frameshift mutation in MUC1 was recently identified as the genetic lesion causing medullary cystic kidney disease type 1, now appropriately renamed MUC1 Kidney Disease. Summary Studies of mucin 1 in the kidney now reveal significant functions for the extracellular mucin-like domain and signaling through the cytoplasmic tail.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2017

Fingerprint

Mucin-1
Kidney
Hypoxia-Inducible Factor 1
Catenins
Mucins
Chronic Renal Insufficiency
Galectins
Frameshift Mutation
Water-Electrolyte Balance
Endosomes
Kidney Diseases
Recycling
Neoplasm Antigens
Calcium Channels
Ion Channels
Polysaccharides
Tail
Fibrosis
Ischemia
Wounds and Injuries

Keywords

  • acute kidney injury
  • chronic kidney disease
  • inflammation
  • MUC1 Kidney Disease
  • mucin 1
  • TRPV5

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

Cite this

Novel roles for mucin 1 in the kidney. / Al-Bataineh, Mohammad M.; Sutton, Timothy; Hughey, Rebecca P.

In: Current Opinion in Nephrology and Hypertension, Vol. 26, No. 5, 01.09.2017, p. 384-391.

Research output: Contribution to journalReview article

Al-Bataineh, Mohammad M. ; Sutton, Timothy ; Hughey, Rebecca P. / Novel roles for mucin 1 in the kidney. In: Current Opinion in Nephrology and Hypertension. 2017 ; Vol. 26, No. 5. pp. 384-391.
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