Novel targets and therapeutic strategies for type 2 diabetes

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The number of people diagnosed with type 2 diabetes mellitus (T2DM) is increasing at an alarming rate in western societies and has become a major health concern. During the past decade, studies using transgenic animals, gene transfer and pharmacological agents have yielded many data that have helped understand the molecular alterations characteristic of T2DM. This has opened the possibility for the development of potentially more-effective therapies, mainly focused on attenuating hepatic glucose production, enhancing glucose-dependent insulin secretion, enhancing the insulin signal transduction pathway, inhibiting lipolysis from the adipose tissue and promoting fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume14
Issue number4
DOIs
StatePublished - May 2003
Externally publishedYes

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Type 2 Diabetes Mellitus
Insulin
Glucose
Genetically Modified Animals
Lipolysis
Adipose Tissue
Signal Transduction
Fatty Acids
Pharmacology
Liver
Health
Therapeutics
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Novel targets and therapeutic strategies for type 2 diabetes. / Morral, Nuria.

In: Trends in Endocrinology and Metabolism, Vol. 14, No. 4, 05.2003, p. 169-175.

Research output: Contribution to journalArticle

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