NR3 protein expression in trigeminal neurons during postnatal development

Kohji Ishihama, Jack E. Turman

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The N-methyl-d-aspartate (NMDA) receptor plays an important role in the generation of rhythmical oral motor activities. To compliment our previous studies, we examined the developmental regulation of NR3A and NR3B expression in trigeminal motoneurons (Mo5) and mesencephalic trigeminal neurons (Me5). NR3A-immunoreactive neurons were observed at all ages in both nuclei, decreasing in Mo5 and caudal Me5 after P14, and increasing in rostral Me5. NR3B protein expression only emerged in Mo5 after P21-23. Results indicate that NR3A and NR3B expression is differentially regulated between Mo5 and Me5 coincident with the transition from suckling to chewing.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalBrain research
Volume1095
Issue number1
DOIs
StatePublished - Jun 16 2006

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Keywords

  • Brainstem
  • Mastication
  • NMDA receptor
  • Oral motor
  • Suckling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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