NSAIDS, aspirin, and esophageal strictures: Are over-the-counter medications harmful to the esophagus?

Suzy L. Kim, John G. Hunter, John Wo, Laurel P. Davis, J. Patrick Waring

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

There are several studies that suggest that aspirin (acetylsalicylic acid [ASA]) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with esophagitis or esophageal stricture formation. There are limited data on the potential of low-dose ASA and over-the-counter (OTC) NSAIDs to cause esophageal injury. The goal of this study was to determine whether there is an association between esophageal strictures and ASA/NSAID use, including low-dose ASA and OTC NSAIDs. A total of 79 consecutive patients (mean age, 52.8 years; 38 men, 41 women) referred for endoscopy from 4/1/96 to 11/15/96 for chronic gastroesophageal reflux disease symptoms were evaluated. Data collected include gender, race, and age, NSAID or ASA use, as well as an assessment of dysphagia, heartburn duration, and heartburn frequency. Patients taking NSAIDs or ASA at least twice a week were considered ASA/NSAID users. There were 46 patients without strictures and 33 patients with peptic strictures. Patients with strictures were older than patients without strictures (mean age, 58.7 versus 48.6 years; p <0.01), had longer duration of heartburn symptoms (8.6 versus 6.4 years, p <0.05), and were more likely to have mucosal injury (50% versus 26.1%). Stricture patients were more likely to use ASA/NSAIDs (63.6% versus 26.1%; p <0.01). In particular, stricture patients were more likely to use low-dose ASA than patients without strictures (30.3% versus 2.2%; p <0.01). Otherwise, there were no significant differences with regard to gender, race, or heartburn duration or frequency. Linear regression analysis showed that ASA/NSAID use had a greater influence on the incidence of peptic strictures than age. There is an association between esophageal stricture and ASA/NSAID use, which includes OTC NSAIDs and low-dose ASA.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalJournal of Clinical Gastroenterology
Volume29
Issue number1
DOIs
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Esophageal Stenosis
Esophagus
Aspirin
Anti-Inflammatory Agents
Pathologic Constriction
Heartburn
Pharmaceutical Preparations
Digestion
Esophagitis
Wounds and Injuries
Deglutition Disorders
Gastroesophageal Reflux
Drug Users
Endoscopy
Linear Models

Keywords

  • Esophageal stricture
  • Nonsteroidals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

NSAIDS, aspirin, and esophageal strictures : Are over-the-counter medications harmful to the esophagus? / Kim, Suzy L.; Hunter, John G.; Wo, John; Davis, Laurel P.; Waring, J. Patrick.

In: Journal of Clinical Gastroenterology, Vol. 29, No. 1, 07.1999, p. 32-34.

Research output: Contribution to journalArticle

Kim, Suzy L. ; Hunter, John G. ; Wo, John ; Davis, Laurel P. ; Waring, J. Patrick. / NSAIDS, aspirin, and esophageal strictures : Are over-the-counter medications harmful to the esophagus?. In: Journal of Clinical Gastroenterology. 1999 ; Vol. 29, No. 1. pp. 32-34.
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