Nuclear protein isoforms

implications for cancer diagnosis and therapy

Fei Shen, Kashif Z. Kirmani, Zhimin Xiao, Benjamin H. Thirlby, Robert J. Hickey, Linda H. Malkas

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Post-translational modifications (PTMs) of nuclear proteins play essential roles in the regulation of gene transcription and signal transduction pathways. Numerous studies have demonstrated a correlation between specific nuclear protein isoforms and cellular malignant process. This communication reviews the impact of major PTM events such as phosphorylation, acetylation, methylation, ubiquitination, and sumoylation on several important nuclear proteins including p53, histones, proliferating cellular nuclear antigen (PCNA), and retinoblastoma protein (Rb) in the process. In addition, the implications of the PTMs as cancer biomarkers and therapeutic targets are considered.

Original languageEnglish
Pages (from-to)756-760
Number of pages5
JournalJournal of Cellular Biochemistry
Volume112
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Nuclear Proteins
Protein Isoforms
Post Translational Protein Processing
Acetylation
Neoplasms
Retinoblastoma Protein
Nuclear Antigens
Signal transduction
Phosphorylation
Methylation
Transcription
Tumor Biomarkers
Sumoylation
Histones
Ubiquitination
Therapeutics
Genes
Signal Transduction
Communication

Keywords

  • Acetylation
  • Methylation
  • Nuclear protein isoforms
  • Phosphorylation
  • Sumoylation
  • Ubiquintination

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Shen, F., Kirmani, K. Z., Xiao, Z., Thirlby, B. H., Hickey, R. J., & Malkas, L. H. (2011). Nuclear protein isoforms: implications for cancer diagnosis and therapy. Journal of Cellular Biochemistry, 112(3), 756-760. https://doi.org/10.1002/jcb.23002

Nuclear protein isoforms : implications for cancer diagnosis and therapy. / Shen, Fei; Kirmani, Kashif Z.; Xiao, Zhimin; Thirlby, Benjamin H.; Hickey, Robert J.; Malkas, Linda H.

In: Journal of Cellular Biochemistry, Vol. 112, No. 3, 03.2011, p. 756-760.

Research output: Contribution to journalArticle

Shen, F, Kirmani, KZ, Xiao, Z, Thirlby, BH, Hickey, RJ & Malkas, LH 2011, 'Nuclear protein isoforms: implications for cancer diagnosis and therapy', Journal of Cellular Biochemistry, vol. 112, no. 3, pp. 756-760. https://doi.org/10.1002/jcb.23002
Shen F, Kirmani KZ, Xiao Z, Thirlby BH, Hickey RJ, Malkas LH. Nuclear protein isoforms: implications for cancer diagnosis and therapy. Journal of Cellular Biochemistry. 2011 Mar;112(3):756-760. https://doi.org/10.1002/jcb.23002
Shen, Fei ; Kirmani, Kashif Z. ; Xiao, Zhimin ; Thirlby, Benjamin H. ; Hickey, Robert J. ; Malkas, Linda H. / Nuclear protein isoforms : implications for cancer diagnosis and therapy. In: Journal of Cellular Biochemistry. 2011 ; Vol. 112, No. 3. pp. 756-760.
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