Nuclear Receptors and the Adaptive Response of the Heart

T. Parry, D. Ledee, M. S. Willis, M. A. Portman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The nuclear receptor (NR) superfamily is involved in a wide range of physiological processes, including homeostasis, development, and metabolism. Since NRs can directly or indirectly interact with DNA, they often play key regulatory roles in health and disease. More recently NRs have been identified in the myocardium, making them interesting pharmacological targets for disease. This chapter explores the different classes and structure of myocardial NRs, their transcription factor-like regulatory mechanisms, the response elements they target, and the processes that regulate them through ligand binding and posttranslational modifications.

Original languageEnglish (US)
Title of host publicationEndocrinology of the Heart in Health and Disease
Subtitle of host publicationIntegrated, Cellular, and Molecular Endocrinology of the Heart
PublisherElsevier Inc.
Number of pages36
ISBN (Electronic)9780128031124
ISBN (Print)9780128031117
StatePublished - Jan 1 2017


  • Cardiac
  • Diabetes mellitus
  • Endocrinology
  • Estrogen receptors
  • Estrogen-related receptors
  • Fibrosis
  • Genes
  • Glucocorticoid receptors
  • Heart
  • Heart failure
  • Inflammation
  • Metabolism
  • Mineralocorticoid receptors
  • Myocardial infarction
  • Nuclear receptor
  • PGC-1
  • PPAR
  • Posttranslational modification
  • Thyroid receptors
  • Ubiquitin
  • Vitamin D receptors

ASJC Scopus subject areas

  • Medicine(all)

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