Nucleotide sequence of the ADH23 gene encoding the human alcohol dehydrogenase β3 subunit

L. G. Carr, Y. Xu, W. H. Ho, Howard Edenberg

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

All nine exons of the ADH23 allele, which encodes the human alcohol dehydrogenase β3 subunit, have been cloned and sequenced. Comparison of this sequence to the ADH21 nucleotide sequence revealed only a single difference that results in an amino acid change, thus proving that the significant kinetic differences between these two isozymes is due to the Cys for Arg substitution at position 369. There are also two silent polymorphisms, and two changes in noncoding regions.

Original languageEnglish
Pages (from-to)594-596
Number of pages3
JournalAlcoholism: Clinical and Experimental Research
Volume13
Issue number4
StatePublished - 1989

Fingerprint

Gene encoding
Alcohol Dehydrogenase
Polymorphism
Isoenzymes
Exons
Substitution reactions
Nucleotides
Alleles
Amino Acids
Kinetics
Genes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Nucleotide sequence of the ADH23 gene encoding the human alcohol dehydrogenase β3 subunit. / Carr, L. G.; Xu, Y.; Ho, W. H.; Edenberg, Howard.

In: Alcoholism: Clinical and Experimental Research, Vol. 13, No. 4, 1989, p. 594-596.

Research output: Contribution to journalArticle

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