All nine exons of the ADH23 allele, which encodes the human alcohol dehydrogenase β3 subunit, have been cloned and sequenced. Comparison of this sequence to the ADH21 nucleotide sequence revealed only a single difference that results in an amino acid change, thus proving that the significant kinetic differences between these two isozymes is due to the Cys for Arg substitution at position 369. There are also two silent polymorphisms, and two changes in noncoding regions.
|Original language||English (US)|
|Number of pages||3|
|Journal||Alcoholism: Clinical and Experimental Research|
|State||Published - Aug 1989|
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Psychiatry and Mental health