Nucleotide Sequence of the ADH23 Gene Encoding the Human Alcohol Dehydrogenase β3 Subunit

Lucinda G. Carr, Yiling Xu, Wei‐Hsien ‐H Ho, Howard J. Edenberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

All nine exons of the ADH23 allele, which encodes the human alcohol dehydrogenase β3 subunit, have been cloned and sequenced. Comparison of this sequence to the ADH21 nucleotide sequence revealed only a single difference that results in an amino acid change, thus proving that the significant kinetic differences between these two isozymes is due to the Cys for Arg substitution at position 369. There are also two silent polymorphisms, and two changes in noncoding regions.

Original languageEnglish (US)
Pages (from-to)594-596
Number of pages3
JournalAlcoholism: Clinical and Experimental Research
Volume13
Issue number4
DOIs
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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