Nucleotide sequence variation in Pneumocystis carinii strains that infect humans

C. H. Lee, J. J. Lu, M. S. Bartlett, M. M. Durkin, T. H. Liu, J. Wang, B. Jiang, J. W. Smith

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Abstract

The nucleotide sequences of a portion of the large-subunit mitochondrial rRNA gene of Pneumocystis carinii derived from 12 patients were examined. Five sequences were found to be identical to the prototype sequence reported by Sinclair et al. (K. Sinclair, A. E. Wakefield, S. Banerji, and J. M. Hopkin, Mol. Biochem. Parasitol. 45:183-184, 1991). Six sequences differed from the prototype sequence at one to three positions. The remaining sequence was markedly different from the prototype sequence and appeared to be a hybrid of the human and rat P. carinii sequences. The results of this study indicate the existence of multiple P. carinii strains infecting humans and suggest that coinfections of animal and human P. carinii strains in the same host are possible.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalJournal of clinical microbiology
Volume31
Issue number3
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)

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    Lee, C. H., Lu, J. J., Bartlett, M. S., Durkin, M. M., Liu, T. H., Wang, J., Jiang, B., & Smith, J. W. (1993). Nucleotide sequence variation in Pneumocystis carinii strains that infect humans. Journal of clinical microbiology, 31(3), 754-757. https://doi.org/10.1128/jcm.31.3.754-757.1993