Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice

Kimberly H. Cox, Kayla M. Quinnies, Alex Eschendroeder, Paula M. Didrick, Erica Eugster, Emilie F. Rissman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sex differences in behavior are widespread and often caused by hormonal differences between the sexes. In addition to hormones, the composition and numbers of the sex chromosomes also affect a variety of sex differences. In humans, X-chromosome genes are implicated in neurobehavioral disorders (i.e. fragile-X, autism). To investigate the role of X-chromosome genes in social behavior, we used a mouse model that has atypical sex chromosome configurations resembling Turner (45, XO) and Klinefelter syndromes (47, XXY). We examined a number of behaviors in juvenile mice. Mice with only one copy of most X-chromosome genes, regardless of gonadal sex, were less social in dyadic interaction and social preference tasks. In the elevated plus maze, mice with one X-chromosome spent less time in the distal ends of the open arms as compared to mice with two copies of X-chromosome genes. Using qRTPCR, we noted that amygdala from female mice with one X-chromosome had higher expression levels of vasopressin (. Avp) as compared to mice in the other groups. Finally, in plasma from girls with Turner syndrome we detected reduced vasopressin (AVP) concentrations as compared to control patients. These novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to our understanding of sex differences in neurobehavioral disorders.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalPsychoneuroendocrinology
Volume51
DOIs
StatePublished - Jan 1 2015

Fingerprint

X-Linked Genes
Social Behavior
Vasopressins
Gene Expression
Sex Characteristics
Sex Chromosomes
Turner Syndrome
X Chromosome
Chromosomes, Human, X
Klinefelter Syndrome
Interpersonal Relations
Autistic Disorder
Amygdala
Hormones
Brain
Genes

Keywords

  • Anxiety
  • Klinefelter syndrome
  • Sex differences
  • Sexual differentiation
  • Social anxiety
  • Social behavior
  • Turner syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice. / Cox, Kimberly H.; Quinnies, Kayla M.; Eschendroeder, Alex; Didrick, Paula M.; Eugster, Erica; Rissman, Emilie F.

In: Psychoneuroendocrinology, Vol. 51, 01.01.2015, p. 271-281.

Research output: Contribution to journalArticle

Cox, Kimberly H. ; Quinnies, Kayla M. ; Eschendroeder, Alex ; Didrick, Paula M. ; Eugster, Erica ; Rissman, Emilie F. / Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice. In: Psychoneuroendocrinology. 2015 ; Vol. 51. pp. 271-281.
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