Nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and Improves Working Memory in Heart Failure

Susan Pressler, Marita Titler, Todd M. Koelling, Penny L. Riley, Miyeon Jung, Lisa Hoyland-Domenico, David L. Ronis, Dean G. Smith, Barry E. Bleske, Susan G. Dorsey, Bruno Giordani

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memory, processing speed, executive function, instrumental activities of daily living, mobility, depressive symptoms, and health-related quality of life. Methods and Results Twenty-seven HF patients were randomly assigned to Brain Fitness and health education active control interventions. Data were collected at baseline and 8 and 12 weeks. Linear mixed models analyses were completed. Patients in the Brain Fitness group were older with lower ejection fraction. At 12 weeks, a group by time interaction effect was found for serum BDNF levels (P =.011): serum BDNF levels increased among patients who completed Brain Fitness and decreased among patients who completed health education. No differences were found in memory, but a group by time interaction (P =.046) effect was found for working memory. Conclusions Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients.

Original languageEnglish (US)
Pages (from-to)630-641
Number of pages12
JournalJournal of Cardiac Failure
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

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Short-Term Memory
Heart Failure
Nurses
Brain
Serum
Health Education
Executive Function
Memory Disorders
Activities of Daily Living
Linear Models
Biomarkers
Quality of Life
Depression

Keywords

  • BDNF
  • computerized cognitive training
  • health-related quality of life
  • Memory loss

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and Improves Working Memory in Heart Failure. / Pressler, Susan; Titler, Marita; Koelling, Todd M.; Riley, Penny L.; Jung, Miyeon; Hoyland-Domenico, Lisa; Ronis, David L.; Smith, Dean G.; Bleske, Barry E.; Dorsey, Susan G.; Giordani, Bruno.

In: Journal of Cardiac Failure, Vol. 21, No. 8, 01.08.2015, p. 630-641.

Research output: Contribution to journalArticle

Pressler, Susan ; Titler, Marita ; Koelling, Todd M. ; Riley, Penny L. ; Jung, Miyeon ; Hoyland-Domenico, Lisa ; Ronis, David L. ; Smith, Dean G. ; Bleske, Barry E. ; Dorsey, Susan G. ; Giordani, Bruno. / Nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and Improves Working Memory in Heart Failure. In: Journal of Cardiac Failure. 2015 ; Vol. 21, No. 8. pp. 630-641.
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