Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects

Nina A. Mikirova, James A. Jackson, Ron Hunninghake, Julian Kenyon, Kyle W.H. Chan, Cathy A. Swindlehurst, Boris Minev, Amit N. Patel, Michael P. Murphy, Leonard Smith, Famela Ramos, Thomas E. Ichim, Neil H. Riordan

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Abstract

The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising preclinical and early clinical data for several degenerative conditions, this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days 1, 2, 7, and 14 subsequent to initiation of administration, which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1/CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors.

Original languageEnglish (US)
Article number34
JournalJournal of Translational Medicine
Volume8
DOIs
StatePublished - Apr 8 2010

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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Mikirova, N. A., Jackson, J. A., Hunninghake, R., Kenyon, J., Chan, K. W. H., Swindlehurst, C. A., Minev, B., Patel, A. N., Murphy, M. P., Smith, L., Ramos, F., Ichim, T. E., & Riordan, N. H. (2010). Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. Journal of Translational Medicine, 8, [34]. https://doi.org/10.1186/1479-5876-8-34