Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects

Nina A. Mikirova, James A. Jackson, Ron Hunninghake, Julian Kenyon, Kyle W H Chan, Cathy A. Swindlehurst, Boris Minev, Amit N. Patel, Michael Murphy, Leonard Smith, Famela Ramos, Thomas E. Ichim, Neil H. Riordan

Research output: Contribution to journalArticle

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Abstract

The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising preclinical and early clinical data for several degenerative conditions, this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days 1, 2, 7, and 14 subsequent to initiation of administration, which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1/CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors.

Original languageEnglish
Article number34
JournalJournal of Translational Medicine
Volume8
DOIs
StatePublished - Apr 8 2010

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Endothelial cells
Dietary Supplements
Hematopoietic Stem Cells
Stem cells
Assays
Granulocyte Colony-Stimulating Factor
Healthy Volunteers
Stem Cells
Staining and Labeling
Costs and Cost Analysis
Costs
Endothelial Progenitor Cells
erucylphosphocholine
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mikirova, N. A., Jackson, J. A., Hunninghake, R., Kenyon, J., Chan, K. W. H., Swindlehurst, C. A., ... Riordan, N. H. (2010). Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. Journal of Translational Medicine, 8, [34]. https://doi.org/10.1186/1479-5876-8-34

Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. / Mikirova, Nina A.; Jackson, James A.; Hunninghake, Ron; Kenyon, Julian; Chan, Kyle W H; Swindlehurst, Cathy A.; Minev, Boris; Patel, Amit N.; Murphy, Michael; Smith, Leonard; Ramos, Famela; Ichim, Thomas E.; Riordan, Neil H.

In: Journal of Translational Medicine, Vol. 8, 34, 08.04.2010.

Research output: Contribution to journalArticle

Mikirova, NA, Jackson, JA, Hunninghake, R, Kenyon, J, Chan, KWH, Swindlehurst, CA, Minev, B, Patel, AN, Murphy, M, Smith, L, Ramos, F, Ichim, TE & Riordan, NH 2010, 'Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects', Journal of Translational Medicine, vol. 8, 34. https://doi.org/10.1186/1479-5876-8-34
Mikirova, Nina A. ; Jackson, James A. ; Hunninghake, Ron ; Kenyon, Julian ; Chan, Kyle W H ; Swindlehurst, Cathy A. ; Minev, Boris ; Patel, Amit N. ; Murphy, Michael ; Smith, Leonard ; Ramos, Famela ; Ichim, Thomas E. ; Riordan, Neil H. / Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. In: Journal of Translational Medicine. 2010 ; Vol. 8.
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