Obesity augments calcium-induced increases in skeletal calcium retention in adolescents

Kathleen M. Hill, Michelle M. Braun, Kara A. Egan, Berdine R. Martin, Linda D. McCabe, Munro Peacock, George P. McCabe, Connie M. Weaver

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Context: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures. Objective: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents. Design: Analysis of pooled data from calcium balance studies in adolescents. Setting: Participants each underwent a 3-wk calcium balance study in a controlled environment. Participants: Participants included 280 White, Black, and Asian boys (n=73) and girls (n=207) ages 10-16 yr. Main Outcome Measure: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression. Results: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention. Conclusions: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents.

Original languageEnglish
Pages (from-to)2171-2177
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number7
DOIs
StatePublished - Jul 1 2011

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Obesity
Calcium
Body Mass Index
Controlled Environment
Dietary Calcium
Pediatric Obesity
Linear regression
Bone Density
Minerals
Linear Models
Bone
Outcome Assessment (Health Care)
Weights and Measures

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Obesity augments calcium-induced increases in skeletal calcium retention in adolescents. / Hill, Kathleen M.; Braun, Michelle M.; Egan, Kara A.; Martin, Berdine R.; McCabe, Linda D.; Peacock, Munro; McCabe, George P.; Weaver, Connie M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 7, 01.07.2011, p. 2171-2177.

Research output: Contribution to journalArticle

Hill, KM, Braun, MM, Egan, KA, Martin, BR, McCabe, LD, Peacock, M, McCabe, GP & Weaver, CM 2011, 'Obesity augments calcium-induced increases in skeletal calcium retention in adolescents', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 7, pp. 2171-2177. https://doi.org/10.1210/jc.2010-2709
Hill, Kathleen M. ; Braun, Michelle M. ; Egan, Kara A. ; Martin, Berdine R. ; McCabe, Linda D. ; Peacock, Munro ; McCabe, George P. ; Weaver, Connie M. / Obesity augments calcium-induced increases in skeletal calcium retention in adolescents. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 7. pp. 2171-2177.
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