Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome

Mira Aubuchon, Jennifer A. Bickhaus, Frank González

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Obesity has grown in pandemic proportions with modern dietary habits and sedentary lifestyle as likely contributors. More recently, epigenetic phenomena have been implicated in the development of obesity. Beyond its energy-storing capacity, the adipose tissue acts as an endocrine and immunological organ. Accumulation of excess adiposity causes dysfunction of the adipose tissue compartment. This dysfunction ultimately leads to immune alterations characterized by inflammation, which then cause metabolic derangement and endocrine imbalance. Obesity increases the risk of developing type 2 diabetes mellitus (DM), dyslipidemia, and hypertension. In polycystic ovary syndrome (PCOS), the presence of obesity exacerbates the signs and symptoms of the disorder by worsening preexisting chronic low-grade inflammation and insulin resistance. In many ways, the metabolic pathophysiology of obesity and PCOS runs in parallel, except that the proinflammatory effects that promote metabolic dysfunction are more pronounced in obesity compared with what is observed in PCOS alone. Nevertheless, diet-induced oxidative stress and inflammation in PCOS that are independent of excess adiposity induce molecular alterations that may be the underpinning of insulin resistance, atherogenesis, and ovarian dysfunction in this disorder.

Original languageEnglish (US)
Title of host publicationPolycystic Ovary Syndrome: Current and Emerging Concepts
PublisherSpringer New York
Pages117-144
Number of pages28
Volume9781461483946
ISBN (Print)9781461483946, 146148393X, 9781461483939
DOIs
StatePublished - Nov 1 2014

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Polycystic Ovary Syndrome
Obesity
Inflammation
Adiposity
Insulin Resistance
Adipose Tissue
Sedentary Lifestyle
Preexisting Condition Coverage
Pandemics
Feeding Behavior
Dyslipidemias
Epigenomics
Type 2 Diabetes Mellitus
Signs and Symptoms
Atherosclerosis
Oxidative Stress
Diet
Hypertension

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

Cite this

Aubuchon, M., Bickhaus, J. A., & González, F. (2014). Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome. In Polycystic Ovary Syndrome: Current and Emerging Concepts (Vol. 9781461483946, pp. 117-144). Springer New York. https://doi.org/10.1007/978-1-4614-8394-6_8

Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome. / Aubuchon, Mira; Bickhaus, Jennifer A.; González, Frank.

Polycystic Ovary Syndrome: Current and Emerging Concepts. Vol. 9781461483946 Springer New York, 2014. p. 117-144.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aubuchon, M, Bickhaus, JA & González, F 2014, Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome. in Polycystic Ovary Syndrome: Current and Emerging Concepts. vol. 9781461483946, Springer New York, pp. 117-144. https://doi.org/10.1007/978-1-4614-8394-6_8
Aubuchon M, Bickhaus JA, González F. Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome. In Polycystic Ovary Syndrome: Current and Emerging Concepts. Vol. 9781461483946. Springer New York. 2014. p. 117-144 https://doi.org/10.1007/978-1-4614-8394-6_8
Aubuchon, Mira ; Bickhaus, Jennifer A. ; González, Frank. / Obesity, metabolic dysfunction, and inflammation in polycystic ovary syndrome. Polycystic Ovary Syndrome: Current and Emerging Concepts. Vol. 9781461483946 Springer New York, 2014. pp. 117-144
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