Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation

R. J. Shah, J. M. Diamond, E. Cantu, J. Flesch, J. C. Lee, D. J. Lederer, V. N. Lama, J. Orens, A. Weinacker, D. S. Wilkes, D. Roe, S. Bhorade, K. M. Wille, L. B. Ware, S. M. Palmer, M. Crespo, E. Demissie, J. Sonnet, A. Shah, S. M. KawutS. L. Bellamy, A. R. Localio, J. D. Christie

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions. 211/1255 subjects in the derivation and 56/382 subjects in the validation developed PGD. We developed three prediction models, where low-risk recipients had a normal BMI (18.5-25 kg/m2), chronic obstructive pulmonary disease/cystic fibrosis, and absent or mild pulmonary hypertension (mPAP

Original languageEnglish (US)
Pages (from-to)2188-2196
Number of pages9
JournalAmerican Journal of Transplantation
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Primary Graft Dysfunction
Lung Transplantation
Transplants
Lung
Pulmonary Hypertension
Cystic Fibrosis
Chronic Obstructive Pulmonary Disease
Logistic Models
Prospective Studies
Mortality

Keywords

  • clinical research / practice
  • lung (allograft) function / dysfunction
  • lung failure / injury
  • lung transplantation / pulmonology

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Shah, R. J., Diamond, J. M., Cantu, E., Flesch, J., Lee, J. C., Lederer, D. J., ... Christie, J. D. (2015). Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplantation, 15(8), 2188-2196. https://doi.org/10.1111/ajt.13262

Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. / Shah, R. J.; Diamond, J. M.; Cantu, E.; Flesch, J.; Lee, J. C.; Lederer, D. J.; Lama, V. N.; Orens, J.; Weinacker, A.; Wilkes, D. S.; Roe, D.; Bhorade, S.; Wille, K. M.; Ware, L. B.; Palmer, S. M.; Crespo, M.; Demissie, E.; Sonnet, J.; Shah, A.; Kawut, S. M.; Bellamy, S. L.; Localio, A. R.; Christie, J. D.

In: American Journal of Transplantation, Vol. 15, No. 8, 01.08.2015, p. 2188-2196.

Research output: Contribution to journalArticle

Shah, RJ, Diamond, JM, Cantu, E, Flesch, J, Lee, JC, Lederer, DJ, Lama, VN, Orens, J, Weinacker, A, Wilkes, DS, Roe, D, Bhorade, S, Wille, KM, Ware, LB, Palmer, SM, Crespo, M, Demissie, E, Sonnet, J, Shah, A, Kawut, SM, Bellamy, SL, Localio, AR & Christie, JD 2015, 'Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation', American Journal of Transplantation, vol. 15, no. 8, pp. 2188-2196. https://doi.org/10.1111/ajt.13262
Shah, R. J. ; Diamond, J. M. ; Cantu, E. ; Flesch, J. ; Lee, J. C. ; Lederer, D. J. ; Lama, V. N. ; Orens, J. ; Weinacker, A. ; Wilkes, D. S. ; Roe, D. ; Bhorade, S. ; Wille, K. M. ; Ware, L. B. ; Palmer, S. M. ; Crespo, M. ; Demissie, E. ; Sonnet, J. ; Shah, A. ; Kawut, S. M. ; Bellamy, S. L. ; Localio, A. R. ; Christie, J. D. / Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. In: American Journal of Transplantation. 2015 ; Vol. 15, No. 8. pp. 2188-2196.
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