Observation of hypertension in children with 21-hydroxylase deficiency: A preliminary report

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Abstract

The most common cause of congenital adrenal hyperplasia is 21-hydroxylase deficiency (21OHD). The prevalence of hypertension (HTN) in children with 21OHD is unknown, and HTN has not been reported to be a component of this disorder. As children with 21OHD are at risk of developing obesity, we hypothesized that an elevated body mass index (BMI) would be a predictive factor in the development of HTN. A retrospective chart review of children with 21OHD seen in our pediatric endocrine clinics for the past 21 yr was performed. Ninety-one children with 21OHD were identified (54% female). Of these children, six (6.6%) had HTN, and five (5.6%) had essential HTN, which was defined as HTN of unknown etiology. Elevated body mass index was not a determining factor in the development of HTN. Children with 21OHD do appear to have a higher prevalence of HTN when compared to historical reports of pediatric populations. The coexistence of HTN with a salt-wasting state and mineralocorticoid deficiency in some children with 21OHD is paradoxical and of unclear etiology.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalEndocrine
Volume30
Issue number3
DOIs
StatePublished - Dec 2006

Fingerprint

Observation
Hypertension
Body Mass Index
Pediatrics
Congenital Adrenal Hyperplasia
Mineralocorticoids
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
Obesity
Salts
Population

Keywords

  • 21-hydroxylase deficiency
  • Body mass index
  • Congenital adrenal hyperplasia
  • Essential hypertension
  • Hypertension
  • Obesity

ASJC Scopus subject areas

  • Endocrinology

Cite this

Observation of hypertension in children with 21-hydroxylase deficiency : A preliminary report. / Nebesio, Todd; Eugster, Erica.

In: Endocrine, Vol. 30, No. 3, 12.2006, p. 279-282.

Research output: Contribution to journalArticle

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