Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers

S. E. Watson, Z. Li, Wanzhu Tu, H. Jalou, J. L. Brubaker, Sandeep Gupta, J. N. Huber, Aaron Carroll, Tamara Hannon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

What is already known about this subject In paediatric patients, obstructive sleep apnoea is associated with adiposity, especially visceral adiposity. In adults, obstructive sleep apnoea is also associated with a higher prevalence of cardiovascular disease and type 2 diabetes. There are limited and conflicting paediatric studies examining the association between obstructive sleep apnoea and biomarkers of risk for cardiovascular disease and type 2 diabetes in youth. What this study adds Obstructive sleep apnoea is linked with greater cardiometabolic risk markers in obese adolescents. Fasting insulin and homeostasis model assessment-insulin resistance may be especially linked with obstructive sleep apnoea among obese male Hispanic adolescents. The relationship between obstructive sleep apnoea and cardiometabolic abnormalities in obese adolescents should be considered when evaluating patients found to have obstructive sleep apnoea. Background Paediatric studies examining the association between obstructive sleep apnoea (OSA) and insulin sensitivity/cardiometabolic risk are limited and conflicting. Objective This study aims to determine if cardiometabolic risk markers are increased among obese youth with obstructive sleep apnoea as compared with their equally obese peers without OSA. Methods We performed a retrospective analysis of 96 patients (age 14.2 ± 1.4 years) who underwent polysomnography for suspected OSA. Fasting lipids, glucose, insulin and haemoglobin A<inf>1</inf>c (HbA<inf>1</inf>c) were performed as part of routine clinical evaluation. Patients were categorized into two groups by degree of OSA as measured by the apnoea-hypopnoea index (AHI): none or mild OSA (AHI < 5) and moderate or severe OSA (AHI ≥ 5). Results Despite the similar degrees of obesity, patients with moderate or severe OSA had higher fasting insulin (P = 0.037) and homeostasis model assessment-insulin resistance (HOMA-IR [P = 0.0497]) as compared with those with mild or no OSA. After controlling for body mass index, there was a positive association between the AHI and log HOMA-IR (P = 0.005). There was a positive relationship between arousals plus awakenings during the polysomnography and fasting triglycerides. Conclusions OSA is linked with greater cardiometabolic risk markers in obese youth.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalPediatric obesity
Volume9
Issue number6
DOIs
StatePublished - Dec 1 2014

Fingerprint

Obstructive Sleep Apnea
Apnea
Fasting
Insulin Resistance
Polysomnography
Adiposity
Insulin
Pediatrics
Type 2 Diabetes Mellitus
Homeostasis
Cardiovascular Diseases
Arousal
Hispanic Americans

Keywords

  • Apnoea
  • insulin sensitivity
  • obesity
  • sleep-disordered breathing

ASJC Scopus subject areas

  • Health Policy
  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics

Cite this

Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers. / Watson, S. E.; Li, Z.; Tu, Wanzhu; Jalou, H.; Brubaker, J. L.; Gupta, Sandeep; Huber, J. N.; Carroll, Aaron; Hannon, Tamara.

In: Pediatric obesity, Vol. 9, No. 6, 01.12.2014, p. 471-477.

Research output: Contribution to journalArticle

Watson, S. E. ; Li, Z. ; Tu, Wanzhu ; Jalou, H. ; Brubaker, J. L. ; Gupta, Sandeep ; Huber, J. N. ; Carroll, Aaron ; Hannon, Tamara. / Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers. In: Pediatric obesity. 2014 ; Vol. 9, No. 6. pp. 471-477.
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