Occupation, pesticide exposure and risk of multiple myeloma

Dalsu Baris, Debra T. Silverman, Linda Morris Brown, G. Marie Swanson, Richard B. Hayes, Ann G. Schwatz, Jonathan M. Liff, Janet B. Schoenberg, Linda M. Pottern, Raymond S. Greenberg, Patricia A. Stewart

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives. This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma. Methods. The study included 573 persons newly diagnosed with myeloma and 2131 controls. Information was obtained on sociodemographic factors, occupational history, and history of living and working on a farm. Occupational and industrial titles were coded by standardized classification systems. A job-exposure matrix was developed for occupational pesticide exposure. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression. Result. Farmers and farm workers had odds ratios of 1.9 (95% CI 0.8-4.6) and 1.4 (95% CI 0.8-2.3), respectively. An odds ratio of 1.7 (95% CI 1.0-2.7) was observed for sheep farm residents or workers, whereas no increased risks were found for cattle, beef, pig, or chicken farm residents or workers. A modestly increased risk was observed for pesticides (OR 1.3, 95% CI 0.9-1.8). Significantly increased risks were found for pharmacists, dieticians and therapists (OR 6.1, 95% CI 1.7-22.5), service occupations (OR 1.3, 95% CI 1.02-1.7), roofers (OR 3.3, 95% CI 1.1-9.8), precision printing occupations (OR 10.1, 95% CI 1.03-99.8), heating equipment operators (OR 4.7, 95% CI 1.4-15.8), and hand molders and casters (OR 3.0, 95% CI 1.0-8.4). Conclusions. A modest increased risk of multiple myeloma is suggested for occupational pesticide exposure. The increased risk for sheep farm residents or workers indicates that certain animal viruses may be involved in myeloma risk.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalScandinavian Journal of Work, Environment and Health
Volume30
Issue number3
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Multiple Myeloma
Occupations
Pesticides
confidence interval
occupation
Farms
pesticide
confidence
Confidence Intervals
Odds Ratio
farm
Heating equipment
Occupational Exposure
resident
Beef
worker
sheep
Sheep
exposure
Viruses

Keywords

  • Case-control study
  • Job-exposure matrix
  • Multiple myeloma
  • Occupational
  • Pesticides

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

Cite this

Baris, D., Silverman, D. T., Brown, L. M., Swanson, G. M., Hayes, R. B., Schwatz, A. G., ... Stewart, P. A. (2004). Occupation, pesticide exposure and risk of multiple myeloma. Scandinavian Journal of Work, Environment and Health, 30(3), 215-222.

Occupation, pesticide exposure and risk of multiple myeloma. / Baris, Dalsu; Silverman, Debra T.; Brown, Linda Morris; Swanson, G. Marie; Hayes, Richard B.; Schwatz, Ann G.; Liff, Jonathan M.; Schoenberg, Janet B.; Pottern, Linda M.; Greenberg, Raymond S.; Stewart, Patricia A.

In: Scandinavian Journal of Work, Environment and Health, Vol. 30, No. 3, 06.2004, p. 215-222.

Research output: Contribution to journalArticle

Baris, D, Silverman, DT, Brown, LM, Swanson, GM, Hayes, RB, Schwatz, AG, Liff, JM, Schoenberg, JB, Pottern, LM, Greenberg, RS & Stewart, PA 2004, 'Occupation, pesticide exposure and risk of multiple myeloma', Scandinavian Journal of Work, Environment and Health, vol. 30, no. 3, pp. 215-222.
Baris D, Silverman DT, Brown LM, Swanson GM, Hayes RB, Schwatz AG et al. Occupation, pesticide exposure and risk of multiple myeloma. Scandinavian Journal of Work, Environment and Health. 2004 Jun;30(3):215-222.
Baris, Dalsu ; Silverman, Debra T. ; Brown, Linda Morris ; Swanson, G. Marie ; Hayes, Richard B. ; Schwatz, Ann G. ; Liff, Jonathan M. ; Schoenberg, Janet B. ; Pottern, Linda M. ; Greenberg, Raymond S. ; Stewart, Patricia A. / Occupation, pesticide exposure and risk of multiple myeloma. In: Scandinavian Journal of Work, Environment and Health. 2004 ; Vol. 30, No. 3. pp. 215-222.
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abstract = "Objectives. This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma. Methods. The study included 573 persons newly diagnosed with myeloma and 2131 controls. Information was obtained on sociodemographic factors, occupational history, and history of living and working on a farm. Occupational and industrial titles were coded by standardized classification systems. A job-exposure matrix was developed for occupational pesticide exposure. Odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) were estimated by unconditional logistic regression. Result. Farmers and farm workers had odds ratios of 1.9 (95{\%} CI 0.8-4.6) and 1.4 (95{\%} CI 0.8-2.3), respectively. An odds ratio of 1.7 (95{\%} CI 1.0-2.7) was observed for sheep farm residents or workers, whereas no increased risks were found for cattle, beef, pig, or chicken farm residents or workers. A modestly increased risk was observed for pesticides (OR 1.3, 95{\%} CI 0.9-1.8). Significantly increased risks were found for pharmacists, dieticians and therapists (OR 6.1, 95{\%} CI 1.7-22.5), service occupations (OR 1.3, 95{\%} CI 1.02-1.7), roofers (OR 3.3, 95{\%} CI 1.1-9.8), precision printing occupations (OR 10.1, 95{\%} CI 1.03-99.8), heating equipment operators (OR 4.7, 95{\%} CI 1.4-15.8), and hand molders and casters (OR 3.0, 95{\%} CI 1.0-8.4). Conclusions. A modest increased risk of multiple myeloma is suggested for occupational pesticide exposure. The increased risk for sheep farm residents or workers indicates that certain animal viruses may be involved in myeloma risk.",
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AU - Brown, Linda Morris

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AU - Hayes, Richard B.

AU - Schwatz, Ann G.

AU - Liff, Jonathan M.

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AB - Objectives. This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma. Methods. The study included 573 persons newly diagnosed with myeloma and 2131 controls. Information was obtained on sociodemographic factors, occupational history, and history of living and working on a farm. Occupational and industrial titles were coded by standardized classification systems. A job-exposure matrix was developed for occupational pesticide exposure. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression. Result. Farmers and farm workers had odds ratios of 1.9 (95% CI 0.8-4.6) and 1.4 (95% CI 0.8-2.3), respectively. An odds ratio of 1.7 (95% CI 1.0-2.7) was observed for sheep farm residents or workers, whereas no increased risks were found for cattle, beef, pig, or chicken farm residents or workers. A modestly increased risk was observed for pesticides (OR 1.3, 95% CI 0.9-1.8). Significantly increased risks were found for pharmacists, dieticians and therapists (OR 6.1, 95% CI 1.7-22.5), service occupations (OR 1.3, 95% CI 1.02-1.7), roofers (OR 3.3, 95% CI 1.1-9.8), precision printing occupations (OR 10.1, 95% CI 1.03-99.8), heating equipment operators (OR 4.7, 95% CI 1.4-15.8), and hand molders and casters (OR 3.0, 95% CI 1.0-8.4). Conclusions. A modest increased risk of multiple myeloma is suggested for occupational pesticide exposure. The increased risk for sheep farm residents or workers indicates that certain animal viruses may be involved in myeloma risk.

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KW - Occupational

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